Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice.
Sci Adv
; 6(33): eabb7238, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-733188
ABSTRACT
Cigarette smoking, the leading cause of chronic obstructive pulmonary disease (COPD), has been implicated as a risk factor for severe disease in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we show that mice with lung epithelial cell-specific loss of function of Miz1, which we identified as a negative regulator of nuclear factor κB (NF-κB) signaling, spontaneously develop progressive age-related changes resembling COPD. Furthermore, loss of Miz1 up-regulates the expression of Ace2, the receptor for SARS-CoV-2. Concomitant partial loss of NF-κB/RelA prevented the development of COPD-like phenotype in Miz1-deficient mice. Miz1 protein levels are reduced in the lungs from patients with COPD, and in the lungs of mice exposed to chronic cigarette smoke. Our data suggest that Miz1 down-regulation-induced sustained activation of NF-κB-dependent inflammation in the lung epithelium is sufficient to induce progressive lung and airway destruction that recapitulates features of COPD, with implications for COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Phenotype
/
Up-Regulation
/
Peptidyl-Dipeptidase A
/
Pulmonary Disease, Chronic Obstructive
/
Ubiquitin-Protein Ligases
/
Epithelial Cells
/
Protein Inhibitors of Activated STAT
/
Kruppel-Like Transcription Factors
/
Lung
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Sci Adv
Year:
2020
Document Type:
Article
Affiliation country:
Sciadv.abb7238
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