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Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients.
Funnell, S G P; Dowling, W E; Muñoz-Fontela, C; Gsell, P-S; Ingber, D E; Hamilton, G A; Delang, L; Rocha-Pereira, J; Kaptein, S; Dallmeier, K H; Neyts, J; Rosenke, K; de Wit, E; Feldmann, H; Maisonnasse, P; Le Grand, R; Frieman, M B; Coleman, C M.
  • Funnell SGP; National Infection Service, Public Health England, Porton Down, Manor Farm Road, Salisbury, Wiltshire, SP40JG, UK. simon.funnell@phe.gov.uk.
  • Dowling WE; Coalition for Epidemic Preparedness Innovations, 1901 Pennsylvania Avenue, NW, Suite 1003, Washington, DC, 20006, USA.
  • Muñoz-Fontela C; Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse. 74, 20359, Hamburg, Germany.
  • Gsell PS; World Health Organisation, Avenue Appia, 1211, Geneva, Switzerland.
  • Ingber DE; Wyss Institute for Biologically Inspired Engineering, Harvard University, CLSB5, 3 Blackfan Circle, Boston, MA, 02115, USA.
  • Hamilton GA; Emulate Inc., 27 Drydock Avenue, 5th Floor, Boston, MA, 02210, USA.
  • Delang L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, KU Leuven, 3000, Leuven, Belgium.
  • Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, KU Leuven, 3000, Leuven, Belgium.
  • Kaptein S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, KU Leuven, 3000, Leuven, Belgium.
  • Dallmeier KH; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, KU Leuven, 3000, Leuven, Belgium.
  • Neyts J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, KU Leuven, 3000, Leuven, Belgium.
  • Rosenke K; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, 59840, MT, USA.
  • de Wit E; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, 59840, MT, USA.
  • Feldmann H; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, 59840, MT, USA.
  • Maisonnasse P; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases ¼ (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, 92265, France.
  • Le Grand R; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases ¼ (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, 92265, France.
  • Frieman MB; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
  • Coleman CM; School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
Nat Commun ; 11(1): 4253, 2020 08 26.
Article in English | MEDLINE | ID: covidwho-733527
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Hydroxychloroquine / Models, Biological Limits: Animals / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-17907-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Hydroxychloroquine / Models, Biological Limits: Animals / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-17907-w