Your browser doesn't support javascript.
Fecal viral shedding in COVID-19 patients: Clinical significance, viral load dynamics and survival analysis.
Wang, Xiaoming; Zheng, Jingwei; Guo, Lei; Yao, Hao; Wang, Lingya; Xia, XiaoDong; Zhang, Weixi.
  • Wang X; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 109 Xueyuan Western Road, Wenzhou 325027, Zhejiang, China.
  • Zheng J; The Affiliated Eye Hospital, Wenzhou Medical University, 270 Xueyuan Western Road, Wenzhou 325027, Zhejiang, China.
  • Guo L; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 109 Xueyuan Western Road, Wenzhou 325027, Zhejiang, China.
  • Yao H; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 109 Xueyuan Western Road, Wenzhou 325027, Zhejiang, China.
  • Wang L; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 109 Xueyuan Western Road, Wenzhou 325027, Zhejiang, China.
  • Xia X; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 109 Xueyuan Western Road, Wenzhou 325027, Zhejiang, China. Electronic address: xia_xiao_dong@hotmail.com.
  • Zhang W; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 109 Xueyuan Western Road, Wenzhou 325027, Zhejiang, China. Electronic address: zhangweixi112@163.com.
Virus Res ; 289: 198147, 2020 11.
Article in English | MEDLINE | ID: covidwho-733589
ABSTRACT

BACKGROUND:

To investigate the clinical significance, viral shedding duration and viral load dynamics of positive fecal SARS-CoV-2 signals in COVID-19.

METHODS:

COVID-19 patients were included. SARS-CoV-2 RNA was tested in stool and respiratory specimens until two sequential negative results were obtained. Clinical, laboratory and imaging data were recorded.

RESULTS:

Of the 69 COVID-19 patients, 20 (28.99 %) had positive fecal viral tests who were younger, had lower C-reactive protein (CRP) and fibrinogen (FIB) levels on admission (all P < 0.05), and showed more improvement and less progression on chest CT during recovery. The median duration of positive viral signals was significantly longer in stool samples than in respiratory samples (P < 0.05). In spite of the negative oropharyngeal swabs, eleven patients were tested positive for viral RNA in stool specimens, with their fecal SARS-CoV-2 RNA Ct (cycle threshold) values reaching 25-27. 6 of these 11 patients' Ct values rebounded.

CONCLUSION:

SARS-CoV-2 RNA in stool specimens was associated with a milder condition and better recovery of chest CT results while the median duration of SARS-CoV-2 RNA persistence was significantly longer in fecal samples than in oropharyngeal swabs. The fecal viral load easily reached a high level and rebounded even though respiratory signals became negative.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / RNA, Viral / Virus Shedding / Coronavirus Infections / Feces / Betacoronavirus Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Virus Res Journal subject: Virology Year: 2020 Document Type: Article Affiliation country: J.virusres.2020.198147

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / RNA, Viral / Virus Shedding / Coronavirus Infections / Feces / Betacoronavirus Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Virus Res Journal subject: Virology Year: 2020 Document Type: Article Affiliation country: J.virusres.2020.198147