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Bioactive pyrrole-based compounds with target selectivity.
Li Petri, Giovanna; Spanò, Virginia; Spatola, Roberto; Holl, Ralph; Raimondi, Maria Valeria; Barraja, Paola; Montalbano, Alessandra.
  • Li Petri G; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
  • Spanò V; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
  • Spatola R; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
  • Holl R; Department of Chemistry, Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146, Hamburg, Germany.
  • Raimondi MV; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy. Electronic address: mariavaleria.raimondi@unipa.it.
  • Barraja P; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
  • Montalbano A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123, Palermo, Italy.
Eur J Med Chem ; 208: 112783, 2020 Dec 15.
Article in English | MEDLINE | ID: covidwho-733870
ABSTRACT
The discovery of novel synthetic compounds with drug-like properties is an ongoing challenge in medicinal chemistry. Natural products have inspired the synthesis of compounds for pharmaceutical application, most of which are based on N-heterocyclic motifs. Among these, the pyrrole ring is one of the most explored heterocycles in drug discovery programs for several therapeutic areas, confirmed by the high number of pyrrole-based drugs reaching the market. In the present review, we focused on pyrrole and its hetero-fused derivatives with anticancer, antimicrobial, and antiviral activities, reported in the literature between 2015 and 2019, for which a specific target was identified, being responsible for their biological activity. It emerges that the powerful pharmaceutical and pharmacological features provided by the pyrrole nucleus as pharmacophore unit of many drugs are still recognized by medicinal chemists.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pyrroles / Molecular Targeted Therapy Limits: Humans Language: English Journal: Eur J Med Chem Year: 2020 Document Type: Article Affiliation country: J.ejmech.2020.112783

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pyrroles / Molecular Targeted Therapy Limits: Humans Language: English Journal: Eur J Med Chem Year: 2020 Document Type: Article Affiliation country: J.ejmech.2020.112783