SARS-CoV-2 and the safety margins of cell-based biological medicinal products.

Modrof, Jens; Kerschbaum, Astrid; Farcet, Maria R; Niemeyer, Daniela; Corman, Victor M; Kreil, Thomas R

Modrof, Jens; Kerschbaum, Astrid; Farcet, Maria R; Niemeyer, Daniela; Corman, Victor M; Kreil, Thomas R.

Modrof J; Global Pathogen Safety, Baxter AG (part of Takeda), Benatzkygasse 2-6, 1221, Vienna, Austria.
Kerschbaum A; Global Pathogen Safety, Baxter AG (part of Takeda), Benatzkygasse 2-6, 1221, Vienna, Austria.
Farcet MR; Global Pathogen Safety, Baxter AG (part of Takeda), Benatzkygasse 2-6, 1221, Vienna, Austria.
Niemeyer D; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and German Centre for Infection Research, Berlin, Germany.
Corman VM; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and German Centre for Infection Research, Berlin, Germany.
Kreil TR; Global Pathogen Safety, Baxter AG (part of Takeda), Benatzkygasse 2-6, 1221, Vienna, Austria. Electronic address: thomas.kreil@takeda.com.

Biologicals ; 68: 122-124, 2020 Nov.

Article in English | MEDLINE | ID: covidwho-733947

ABSTRACT

ABSTRACT

With the pandemic emergence of SARS-CoV-2, the exposure of cell substrates used for manufacturing of medicines has become a possibility. Cell lines used in biomanufacturing were thus evaluated for their SARS-CoV-2 susceptibility, and the detection of SARS-CoV-2 in culture supernatants by routine adventitious virus testing of fermenter harvest tested.

Subject(s)

Betacoronavirus/physiology; Coronavirus Infections/metabolism; Pneumonia, Viral/metabolism; Virus Replication; Animals; Antiviral Agents/pharmacology; Biological Factors/pharmacology; CHO Cells; COVID-19; Chlorocebus aethiops; Coronavirus Infections/drug therapy; Cricetulus; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Pandemics; Pneumonia, Viral/drug therapy; SARS-CoV-2; Vero Cells

Keywords

AAT; Adventitious agent testing; Biomedical products; CHO; Cell lines; HEK-293; HT-1080; Permissiveness; SARS-CoV-2; Safety; Susceptibility; Vero

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Virus Replication / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study / Experimental Studies / Prognostic study Topics: Traditional medicine Limits: Animals / Humans Language: English Journal: Biologicals Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: J.biologicals.2020.08.010

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