Is Sex a Determinant of COVID-19 Infection? Truth or Myth?
Curr Hypertens Rep
; 22(9): 62, 2020 08 27.
Article
in English
| MEDLINE | ID: covidwho-734061
ABSTRACT
PURPOSE OF REVIEW Angiotensin-converting enzyme 2 (ACE2), a specific high-affinity angiotensin II-hydrolytic enzyme, is the vector that facilitates cellular entry of SARS-CoV-1 and the novel SARS-CoV-2 coronavirus. SARS-CoV-2, which crossed species barriers to infect humans, is highly contagious and associated with high lethality due to multi-organ failure, mostly in older patients with other co-morbidities. RECENT FINDINGS:
Accumulating clinical evidence demonstrates that the intensity of the infection and its complications are more prominent in men. It has been postulated that potential functional modulation of ACE2 by estrogen may explain the sex difference in morbidity and mortality. We review here the evidence regarding the role of estrogenic hormones in ACE2 expression and regulation, with the intent of bringing to the forefront potential mechanisms that may explain sex differences in SARS-CoV-2 infection and COVID-19 outcomes, assist in management of COVID-19, and uncover new therapeutic strategies.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Sex Factors
/
Coronavirus Infections
/
Peptidyl-Dipeptidase A
/
Estrogens
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Curr Hypertens Rep
Journal subject:
Vascular Diseases
Year:
2020
Document Type:
Article
Affiliation country:
S11906-020-01073-x
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