High density of IgG4-secreting plasma cells in the fibrotic tissue from a surgically resected tracheal ring impaired by complex subglottic stenosis post-tracheostomy as immune expression of a T<sub>h</sub>2 response due to severe COVID-19.

Roncati, Luca; Bergonzini, Giuliano; Lusenti, Beatrice; Nasillo, Vincenzo; Paolini, Ambra; Zanelli, Giuliana; Corrado, Stefania

High density of IgG4-secreting plasma cells in the fibrotic tissue from a surgically resected tracheal ring impaired by complex subglottic stenosis post-tracheostomy as immune expression of a T_h2 response due to severe COVID-19.

Roncati, Luca; Bergonzini, Giuliano; Lusenti, Beatrice; Nasillo, Vincenzo; Paolini, Ambra; Zanelli, Giuliana; Corrado, Stefania.

Roncati L; Hemolymphopathology Team, University Hospital of Modena, Largo del Pozzo 71, 41124, Modena, Italy. roncati.luca@aou.mo.it.
Bergonzini G; Surgical Pathology, University Hospital of Modena, Modena, Italy. roncati.luca@aou.mo.it.
Lusenti B; Clinical Pathology, University Hospital of Modena, Modena, Italy.
Nasillo V; Hemolymphopathology Team, University Hospital of Modena, Largo del Pozzo 71, 41124, Modena, Italy.
Paolini A; Hemolymphopathology Team, University Hospital of Modena, Largo del Pozzo 71, 41124, Modena, Italy.
Zanelli G; Hemolymphopathology Team, University Hospital of Modena, Largo del Pozzo 71, 41124, Modena, Italy.
Corrado S; Surgical Pathology, University Hospital of Modena, Modena, Italy.

Ann Hematol ; 100(10): 2659-2660, 2021 Oct.

Article in English | MEDLINE | ID: covidwho-734105

Subject(s)

COVID-19/immunology; Immunoglobulin G/analysis; Laryngostenosis/immunology; Plasma Cells/immunology; SARS-CoV-2; Th2 Cells/immunology; Trachea/immunology; Tracheostomy/adverse effects; Aged; Cicatrix/etiology; Cicatrix/immunology; Diagnosis, Differential; Fibrosis; Humans; Immunoglobulin G4-Related Disease/diagnosis; Laryngostenosis/etiology; Laryngostenosis/pathology; Male; Plasma Cells/pathology; Trachea/pathology; Trachea/surgery

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plasma Cells / Trachea / Immunoglobulin G / Tracheostomy / Laryngostenosis / Th2 Cells / SARS-CoV-2 / COVID-19 Type of study: Case report / Diagnostic study Limits: Aged / Humans / Male Language: English Journal: Ann Hematol Journal subject: Hematology Year: 2021 Document Type: Article Affiliation country: S00277-020-04231-y

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