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Entry Inhibitors: Efficient Means to Block Viral Infection.
Pattnaik, Gourab Prasad; Chakraborty, Hirak.
  • Pattnaik GP; School of Chemistry, Sambalpur University, Jyoti Vihar, Burla, Odisha, 768 019, India.
  • Chakraborty H; School of Chemistry, Sambalpur University, Jyoti Vihar, Burla, Odisha, 768 019, India. hirak@suniv.ac.in.
J Membr Biol ; 253(5): 425-444, 2020 10.
Article in English | MEDLINE | ID: covidwho-734824
ABSTRACT
The emerging and re-emerging viral infections are constant threats to human health and wellbeing. Several strategies have been explored to develop vaccines against these viral diseases. The main effort in the journey of development of vaccines is to neutralize the fusion protein using antibodies. However, significant efforts have been made in discovering peptides and small molecules that inhibit the fusion between virus and host cell, thereby inhibiting the entry of viruses. This class of inhibitors is called entry inhibitors, and they are extremely efficient in reducing viral infection as the entry of the virus is considered as the first step of infection. Nevertheless, these inhibitors are highly selective for a particular virus as antibody-based vaccines. The recent COVID-19 pandemic lets us ponder to shift our attention towards broad-spectrum antiviral agents from the so-called 'one bug-one drug' approach. This review discusses peptide and small molecule-based entry inhibitors against class I, II, and III viruses and sheds light on broad-spectrum antiviral agents.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Coronavirus Infections / Virus Internalization / Betacoronavirus / Membrane Fusion Type of study: Observational study Topics: Vaccines Limits: Humans Language: English Journal: J Membr Biol Year: 2020 Document Type: Article Affiliation country: S00232-020-00136-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Coronavirus Infections / Virus Internalization / Betacoronavirus / Membrane Fusion Type of study: Observational study Topics: Vaccines Limits: Humans Language: English Journal: J Membr Biol Year: 2020 Document Type: Article Affiliation country: S00232-020-00136-z