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A systematic review and meta-analysis of the COVID-19 associated liver injury.
Wong, Yu Jun; Tan, Malcolm; Zheng, Qishi; Li, James Weiquan; Kumar, Rahul; Fock, Kwong Ming; Teo, Eng Kiong; Ang, Tiing Leong.
  • Wong YJ; Department of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore. Electronic address: eugene.wong.y.j@singhealth.com.sg.
  • Tan M; Department of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore.
  • Zheng Q; Singapore Clinical Research Institute; Cochrane Singapore.
  • Li JW; Department of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore.
  • Kumar R; Department of Gastroenterology and Hepatology, Changi General Hospital.
  • Fock KM; Department of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore; Cochrane Singapore.
  • Teo EK; Department of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore.
  • Ang TL; Department of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore.
Ann Hepatol ; 19(6): 627-634, 2020.
Article in English | MEDLINE | ID: covidwho-734954
ABSTRACT
INTRODUCTION AND

OBJECTIVES:

The novel coronavirus disease 2019 (COVID-19) has affected more than 5 million people globally. Data on the prevalence and degree of COVID-19 associated liver injury among patients with COVID-19 remain limited. We conducted a systematic review and meta-analysis to assess the prevalence and degree of liver injury between patients with severe and non-severe COVID-19.

METHODS:

We performed a systematic search of three electronic databases (PubMed/MEDLINE, EMBASE and Cochrane Library), from inception to 24th April 2020. We included all adult human studies (>20 subjects) regardless of language, region or publication date or status. We assessed the pooled odds ratio (OR), mean difference (MD) and 95% confidence interval (95%CI) using the random-effects model.

RESULTS:

Among 1543 citations, there were 24 studies (5961 subjects) which fulfilled our inclusion criteria. The pooled odds ratio for elevated ALT (OR = 2.5, 95%CI 1.6-3.7, I2 = 57%), AST (OR = 3.4, 95%CI 2.3-5.0, I2 = 56%), hyperbilirubinemia (OR = 1.7, 95%CI 1.2-2.5, I2 = 0%) and hypoalbuminemia (OR = 7.1, 95%CI 2.1-24.1, I2 = 71%) were higher subjects in critical COVID-19.

CONCLUSION:

COVID-19 associated liver injury is more common in severe COVID-19 than non-severe COVID-19. Physicians should be aware of possible progression to severe disease in subjects with COVID-19-associated liver injury.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Liver Diseases Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: Ann Hepatol Journal subject: Gastroenterology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Liver Diseases Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: Ann Hepatol Journal subject: Gastroenterology Year: 2020 Document Type: Article