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Anticoagulation in COVID-19: A Systematic Review, Meta-analysis, and Rapid Guidance From Mayo Clinic.
McBane, Robert D; Torres Roldan, Victor D; Niven, Alexander S; Pruthi, Rajiv K; Franco, Pablo Moreno; Linderbaum, Jane A; Casanegra, Ana I; Oyen, Lance J; Houghton, Damon E; Marshall, Ariela L; Ou, Narith N; Siegel, Jason L; Wysokinski, Waldemar E; Padrnos, Leslie J; Rivera, Candido E; Flo, Gayle L; Shamoun, Fadi E; Silvers, Scott M; Nayfeh, Tarek; Urtecho, Meritxell; Shah, Sahrish; Benkhadra, Raed; Saadi, Samer Mohir; Firwana, Mohammed; Jawaid, Tabinda; Amin, Mustapha; Prokop, Larry J; Murad, M Hassan.
  • McBane RD; Gonda Vascular Center, Mayo Clinic, Rochester, MN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
  • Torres Roldan VD; Evidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
  • Niven AS; Division of Pulmonary and Critical Care, Center for Sleep Medicine, Mayo Clinic, Rochester, MN.
  • Pruthi RK; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; Division of Hematology, Mayo Clinic, Rochester, MN.
  • Franco PM; Transplant Critical Care Medicine, Mayo Clinic, Jacksonville, FL.
  • Linderbaum JA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
  • Casanegra AI; Gonda Vascular Center, Mayo Clinic, Rochester, MN; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
  • Oyen LJ; Department of Pharmacy, Mayo Clinic, Rochester, MN.
  • Houghton DE; Gonda Vascular Center, Mayo Clinic, Rochester, MN; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
  • Marshall AL; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; Division of Hematology, Mayo Clinic, Rochester, MN.
  • Ou NN; Department of Pharmacy, Mayo Clinic, Rochester, MN.
  • Siegel JL; Department of Neurology, Mayo Clinic, Jacksonville, FL.
  • Wysokinski WE; Gonda Vascular Center, Mayo Clinic, Rochester, MN; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
  • Padrnos LJ; Division of Hematology, Mayo Clinic, Scottsdale, AZ.
  • Rivera CE; Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL.
  • Flo GL; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
  • Shamoun FE; Department of Cardiovascular Medicine, Mayo Clinic, Scottsdale, AZ.
  • Silvers SM; Department of Emergency Medicine, Mayo Clinic, Jacksonville, FL.
  • Nayfeh T; Evidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
  • Urtecho M; Evidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
  • Shah S; Evidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
  • Benkhadra R; Evidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
  • Saadi SM; Evidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
  • Firwana M; Evidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
  • Jawaid T; Evidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
  • Amin M; Evidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
  • Prokop LJ; Mayo Clinic Libraries, Mayo Clinic, Rochester, MN.
  • Murad MH; Evidence-based Practice Center and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN. Electronic address: murad.mohammad@mayo.edu.
Mayo Clin Proc ; 95(11): 2467-2486, 2020 11.
Article in English | MEDLINE | ID: covidwho-735313
ABSTRACT
A higher risk of thrombosis has been described as a prominent feature of coronavirus disease 2019 (COVID-19). This systematic review synthesizes current data on thrombosis risk, prognostic implications, and anticoagulation effects in COVID-19. We included 37 studies from 4070 unique citations. Meta-analysis was performed when feasible. Coagulopathy and thrombotic events were frequent among patients with COVID-19 and further increased in those with more severe forms of the disease. We also present guidance on the prevention and management of thrombosis from a multidisciplinary panel of specialists from Mayo Clinic. The current certainty of evidence is generally very low and continues to evolve.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Practice Guidelines as Topic / SARS-CoV-2 / COVID-19 Drug Treatment / Anticoagulants Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Country/Region as subject: North America Language: English Journal: Mayo Clin Proc Year: 2020 Document Type: Article Affiliation country: J.mayocp.2020.08.030

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Practice Guidelines as Topic / SARS-CoV-2 / COVID-19 Drug Treatment / Anticoagulants Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Country/Region as subject: North America Language: English Journal: Mayo Clin Proc Year: 2020 Document Type: Article Affiliation country: J.mayocp.2020.08.030