COVID-19 and diabetes; Possible role of polymorphism and rise of telemedicine.
Prim Care Diabetes
; 15(1): 4-9, 2021 02.
Article
in English
| MEDLINE | ID: covidwho-735354
ABSTRACT
BACKGROUND:
Diabetes has been found to be one of the leading comorbidities associated with fatality in COVID-19 patients. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry is facilitated by interaction with Angiotensin Converting Enzyme-2 (ACE2) and possible polymorphisms in ACE2 can be a determining factor in host-viral protein interaction. A significant shift of healthcare towards 'Telemedicine' is also on the rise. In this review, the possible effects of ACE2 polymorphisms on SARS-CoV-2 entry along with the escalation of 'telemedicine' is discussed.METHOD:
An expansive literature search using keywords "COVID-19", "SARS-CoV-2", "diabetes", "type 2 diabetes'', "type 1 diabetes", "ACE2", "polymorphism", "DPP4" and "telemedicine" was conducted on Pubmed and EMBASE till 7th August 2020.RESULT:
Possible polymorphisms in ACE2 gene can play a role in influencing the virus entry in host body. Telemedicine can bring a new revolution for medical sector.CONCLUSION:
COVID-19 severity is more heinous among diabetic population. So far, the in-silico studies involving human ACE2-viral Spike (S) interaction showed inconsistent predictions regarding some SNPs. But without actual in-vivo studies, a holistic understanding can't be established.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
DNA
/
Telemedicine
/
Diabetes Mellitus, Type 2
/
Pandemics
/
Angiotensin-Converting Enzyme 2
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Reviews
Limits:
Humans
Language:
English
Journal:
Prim Care Diabetes
Journal subject:
Endocrinology
Year:
2021
Document Type:
Article
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