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Human post-infection serological response to the spike and nucleocapsid proteins of SARS-CoV-2.
Xiao, Cheng; Ling, Shiman; Qiu, Minshan; Deng, Zhenxuan; Chen, Liping; Zhu, Airu; Chen, Yi; Liu, Yong; Lin, Xia; Lin, Fangmei; Wu, Qiubao; Shen, Lihan; Ye, Feng; Liu, Xiaoqing; Li, Yimin; Zhao, Jincun; Yang, Zifeng; Cowling, Benjamin J; Webby, Richard; Zanin, Mark; Wong, Sook-San.
  • Xiao C; Guangzhou Medical University, Guangzhou, China.
  • Ling S; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Qiu M; Guangzhou Medical University, Guangzhou, China.
  • Deng Z; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Chen L; Department of Intensive Care, Dongguan People's Hospital, Dongguan, China.
  • Zhu A; Department of Intensive Care, Dongguan People's Hospital, Dongguan, China.
  • Chen Y; Guangzhou Medical University, Guangzhou, China.
  • Liu Y; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Lin X; Guangzhou Medical University, Guangzhou, China.
  • Lin F; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Wu Q; Central Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Shen L; Guangzhou Medical University, Guangzhou, China.
  • Ye F; Kingmed Virology Diagnostics and Translational Center, Guangzhou Kingmed Center for Clinical Laboratory, Guangzhou, China.
  • Liu X; Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Li Y; Guangzhou Medical University, Guangzhou, China.
  • Zhao J; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Yang Z; Guangzhou Medical University, Guangzhou, China.
  • Cowling BJ; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Webby R; Guangzhou Medical University, Guangzhou, China.
  • Zanin M; Nanshan Medicine Innovation, Guangdong, China.
  • Wong SS; Department of Intensive Care, Dongguan People's Hospital, Dongguan, China.
Influenza Other Respir Viruses ; 15(1): 7-12, 2021 01.
Article in English | MEDLINE | ID: covidwho-735924
ABSTRACT
To inform seroepidemiological studies, we characterized the IgG- responses in COVID-19 patients against the two major SARS-CoV-2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 COVID-19 sera collected up to 85 days post-symptom onset and 230 non-COVID-19 sera, including 27 SARS sera from 2003. Although the average SARS-CoV-2 S and N-IgG titers were comparable, N-responses were more variable among individuals. S- and N-assay specificity tested with non-COVID-19 sera were comparable at 97.5% and 97.0%, respectively. Therefore, S will make a better target due to its lower cross-reactive potential and its' more consistent frequency of detection compared to N.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / Antibodies, Viral Type of study: Diagnostic study / Observational study / Randomized controlled trials Limits: Adult / Aged / Humans / Middle aged Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Irv.12798

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / Antibodies, Viral Type of study: Diagnostic study / Observational study / Randomized controlled trials Limits: Adult / Aged / Humans / Middle aged Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Irv.12798