Transcriptomic analysis of COVID19 lungs and bronchoalveolar lavage fluid samples reveals predominant B cell activation responses to infection.
Int J Mol Med
; 46(4): 1266-1273, 2020 Oct.
Article
in English
| MEDLINE | ID: covidwho-736764
ABSTRACT
The outbreak of the 2019 coronavirus disease (named, COVID19), caused by the novel SARSCoV2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARSCoV2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for COVID19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARSCoV2 infection may further improve our understanding of COVID19 pathogenesis and suggest better therapeutic strategies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
B-Lymphocytes
/
Lymphocyte Activation
/
Coronavirus Infections
/
Transcriptome
/
Betacoronavirus
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Int J Mol Med
Journal subject:
Molecular Biology
/
Genetics, Medical
Year:
2020
Document Type:
Article
Affiliation country:
Ijmm.2020.4702
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