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Antiviral treatment for COVID-19: the evidence supporting remdesivir.
Richardson, Charlotte; Bhagani, Sanjay; Pollara, Gabriele.
  • Richardson C; Royal Free London NHS Foundation Trust charlotterichardson1@nhs.net.
  • Bhagani S; Royal Free London NHS Foundation Trust, and honorary senior lecturer, University College London.
  • Pollara G; Royal Free London NHS Foundation Trust, and Wellcome Trust postdoctoral clinical research fellow and NIHR clinical lecturer, University College London.
Clin Med (Lond) ; 20(6): e215-e217, 2020 11.
Article in English | MEDLINE | ID: covidwho-736877
ABSTRACT
The emergence of the novel beta coronavirus SARS-CoV-2 and the ensuing COVID-19 pandemic has generated a rapidly evolving research landscape in the search for new therapeutic agents. The intravenous antiviral drug remdesivir has in vitro activity against SARS-CoV-2 and now studies have reported its clinical efficacy, demonstrating shorter time to recovery in hospitalised patients with severe COVID-19. Adverse event rates were low and remdesivir has now received conditional marketing authorisation from the European Medicines Agency. An interim clinical commissioning policy is in place in the UK. These studies make remdesivir the first antiviral drug able to alter the natural history of severe COVID-19, and a benchmark for the comparison of new therapies in the future. Ongoing studies are investigating its use in early mild/moderate COVID-19, alternative formulations, and the combination of remdesivir with immunomodulatory agents.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Adenosine Monophosphate / Coronavirus Infections / Alanine Type of study: Prognostic study / Randomized controlled trials Limits: Female / Humans / Male / Middle aged Language: English Journal: Clin Med (Lond) Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Adenosine Monophosphate / Coronavirus Infections / Alanine Type of study: Prognostic study / Randomized controlled trials Limits: Female / Humans / Male / Middle aged Language: English Journal: Clin Med (Lond) Year: 2020 Document Type: Article