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A 57-Year-Old African American Man with Severe COVID-19 Pneumonia Who Responded to Supportive Photobiomodulation Therapy (PBMT): First Use of PBMT in COVID-19.
Sigman, Scott A; Mokmeli, Soheila; Monici, Monica; Vetrici, Mariana A.
  • Sigman SA; Team Physician, UMASS Lowell, Fellow of the World Society of Sports and Exercise Medicine, Fellow of the Royal College of Surgeons in Ireland, Chelmsford, MA, USA.
  • Mokmeli S; Training Institute, Canadian Optic and Laser Center, Victoria, BC, Canada.
  • Monici M; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
  • Vetrici MA; Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada.
Am J Case Rep ; 21: e926779, 2020 Aug 15.
Article in English | MEDLINE | ID: covidwho-736892
Semantic information from SemMedBD (by NLM)
1. Low-Level Light Therapy ADMINISTERED_TO Male population group
Subject
Low-Level Light Therapy
Predicate
ADMINISTERED_TO
Object
Male population group
2. Pneumonia PROCESS_OF Male population group
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Male population group
3. Low-Level Light Therapy TREATS COVID-19
Subject
Low-Level Light Therapy
Predicate
TREATS
Object
COVID-19
4. Lung diseases PROCESS_OF Patients
Subject
Lung diseases
Predicate
PROCESS_OF
Object
Patients
5. Low-Level Light Therapy PREVENTS Inflammation
Subject
Low-Level Light Therapy
Predicate
PREVENTS
Object
Inflammation
6. Scanning Systems USES Lasers
Subject
Scanning Systems
Predicate
USES
Object
Lasers
7. COVID-19 PROCESS_OF Male population group
Subject
COVID-19
Predicate
PROCESS_OF
Object
Male population group
8. Supportive care TREATS Pneumonia
Subject
Supportive care
Predicate
TREATS
Object
Pneumonia
9. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
10. Supportive care TREATS Patients
Subject
Supportive care
Predicate
TREATS
Object
Patients
11. oxygen TREATS Several days
Subject
oxygen
Predicate
TREATS
Object
Several days
12. Low-Level Light Therapy TREATS Pneumonia
Subject
Low-Level Light Therapy
Predicate
TREATS
Object
Pneumonia
13. Low-Level Light Therapy TREATS Patients
Subject
Low-Level Light Therapy
Predicate
TREATS
Object
Patients
14. Low-Level Light Therapy ADMINISTERED_TO Male population group
Subject
Low-Level Light Therapy
Predicate
ADMINISTERED_TO
Object
Male population group
15. Pneumonia PROCESS_OF Male population group
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Male population group
16. Low-Level Light Therapy TREATS COVID-19
Subject
Low-Level Light Therapy
Predicate
TREATS
Object
COVID-19
17. Lung diseases PROCESS_OF Patients
Subject
Lung diseases
Predicate
PROCESS_OF
Object
Patients
18. Low-Level Light Therapy PREVENTS Inflammation
Subject
Low-Level Light Therapy
Predicate
PREVENTS
Object
Inflammation
19. Scanning Systems USES Lasers
Subject
Scanning Systems
Predicate
USES
Object
Lasers
20. COVID-19 PROCESS_OF Male population group
Subject
COVID-19
Predicate
PROCESS_OF
Object
Male population group
21. Supportive care TREATS Pneumonia
Subject
Supportive care
Predicate
TREATS
Object
Pneumonia
22. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
23. Supportive care TREATS Patients
Subject
Supportive care
Predicate
TREATS
Object
Patients
24. oxygen TREATS Several days
Subject
oxygen
Predicate
TREATS
Object
Several days
25. Low-Level Light Therapy TREATS Pneumonia
Subject
Low-Level Light Therapy
Predicate
TREATS
Object
Pneumonia
26. Low-Level Light Therapy TREATS Patients
Subject
Low-Level Light Therapy
Predicate
TREATS
Object
Patients
ABSTRACT
BACKGROUND Coronavirus disease 2019 (COVID-19) is associated with lung inflammation and cytokine storm. Photobiomodulation therapy (PBMT) is a safe, non-invasive therapy with significant anti-inflammatory effects. Adjunct PBMT has been employed in treating patients with lung conditions. Human studies and experimental models of respiratory disease suggest PBMT reduces inflammation and promotes lung healing. This is the first time supportive PBMT was used in a severe case of COVID-19 pneumonia. CASE REPORT A 57-year-old African American man with severe COVID-19 received 4 once-daily PBMT sessions by a laser scanner with pulsed 808 nm and super-pulsed 905 nm modes for 28 min. The patient was evaluated before and after treatment via radiological assessment of lung edema (RALE) by CXR, pulmonary severity indices, blood tests, oxygen requirements, and patient questionnaires. Oxygen saturation (SpO2) increased from 93-94% to 97-100%, while the oxygen requirement decreased from 2-4 L/min to 1 L/min. The RALE score improved from 8 to 5. The Pneumonia Severity Index improved from Class V (142) to Class II (67). Additional pulmonary indices (Brescia-COVID and SMART-COP) both decreased from 4 to 0. CRP normalized from 15.1 to 1.23. The patient reported substantial improvement in the Community-Acquired Pneumonia assessment tool. CONCLUSIONS This report has presented supportive PBMT in a patient with severe COVID-19 pneumonia. Respiratory indices, radiological findings, oxygen requirements, and patient outcomes improved over several days and without need for a ventilator. Future controlled clinical trials are required to evaluate the effects of PBMT on clinical outcomes in patients with COVID-19 pneumonia.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / African Americans / Coronavirus Infections / Low-Level Light Therapy / Betacoronavirus Type of study: Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Am J Case Rep Year: 2020 Document Type: Article Affiliation country: AJCR.926779

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / African Americans / Coronavirus Infections / Low-Level Light Therapy / Betacoronavirus Type of study: Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Am J Case Rep Year: 2020 Document Type: Article Affiliation country: AJCR.926779