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Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress.
Hahad, Omar; Lelieveld, Jos; Birklein, Frank; Lieb, Klaus; Daiber, Andreas; Münzel, Thomas.
  • Hahad O; Center for Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
  • Lelieveld J; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 55131 Mainz, Germany.
  • Birklein F; Atmospheric Chemistry Department, Max Planck Institute for Chemistry, 55128 Mainz, Germany.
  • Lieb K; Climate and Atmosphere Research Center, The Cyprus Institute, Nicosia 1645, Cyprus.
  • Daiber A; Department of Neurology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
  • Münzel T; Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Int J Mol Sci ; 21(12)2020 Jun 17.
Article in English | MEDLINE | ID: covidwho-738129
Semantic information from SemMedBD (by NLM)
1. Disease CAUSES Inflammation
Subject
Disease
Predicate
CAUSES
Object
Inflammation
2. Air Pollution CAUSES Widespread Disease
Subject
Air Pollution
Predicate
CAUSES
Object
Widespread Disease
3. Evaluation AFFECTS Increased risk
Subject
Evaluation
Predicate
AFFECTS
Object
Increased risk
4. Inflammation CAUSES Disease
Subject
Inflammation
Predicate
CAUSES
Object
Disease
5. Oxidative Stress CAUSES Disease
Subject
Oxidative Stress
Predicate
CAUSES
Object
Disease
6. Air Pollution CAUSES Disease
Subject
Air Pollution
Predicate
CAUSES
Object
Disease
7. Disease CAUSES Inflammation
Subject
Disease
Predicate
CAUSES
Object
Inflammation
8. Air Pollution CAUSES Widespread Disease
Subject
Air Pollution
Predicate
CAUSES
Object
Widespread Disease
9. Evaluation AFFECTS Increased risk
Subject
Evaluation
Predicate
AFFECTS
Object
Increased risk
10. Inflammation CAUSES Disease
Subject
Inflammation
Predicate
CAUSES
Object
Disease
11. Oxidative Stress CAUSES Disease
Subject
Oxidative Stress
Predicate
CAUSES
Object
Disease
12. Air Pollution CAUSES Disease
Subject
Air Pollution
Predicate
CAUSES
Object
Disease
ABSTRACT
Exposure to ambient air pollution is a well-established determinant of health and disease. The Lancet Commission on pollution and health concludes that air pollution is the leading environmental cause of global disease and premature death. Indeed, there is a growing body of evidence that links air pollution not only to adverse cardiorespiratory effects but also to increased risk of cerebrovascular and neuropsychiatric disorders. Despite being a relatively new area of investigation, overall, there is mounting recent evidence showing that exposure to multiple air pollutants, in particular to fine particles, may affect the central nervous system (CNS) and brain health, thereby contributing to increased risk of stroke, dementia, Parkinson's disease, cognitive dysfunction, neurodevelopmental disorders, depression and other related conditions. The underlying molecular mechanisms of susceptibility and disease remain largely elusive. However, emerging evidence suggests inflammation and oxidative stress to be crucial factors in the pathogenesis of air pollution-induced disorders, driven by the enhanced production of proinflammatory mediators and reactive oxygen species in response to exposure to various air pollutants. From a public health perspective, mitigation measures are urgent to reduce the burden of disease and premature mortality from ambient air pollution.
Subject(s)
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cerebrovascular Disorders / Oxidative Stress / Air Pollutants / Air Pollution / Mental Disorders Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21124306

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cerebrovascular Disorders / Oxidative Stress / Air Pollutants / Air Pollution / Mental Disorders Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21124306