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Possible routes of SARS-CoV-2 invasion in brain: In context of neurological symptoms in COVID-19 patients.
Kumar, Ashutosh; Pareek, Vikas; Prasoon, Pranav; Faiq, Muneeb A; Kumar, Pavan; Kumari, Chiman; Narayan, Ravi K.
  • Kumar A; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.
  • Pareek V; Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Patna, India.
  • Prasoon P; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.
  • Faiq MA; National Brain Research Center, Manesar, India.
  • Kumar P; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.
  • Kumari C; Pittsburgh Center for Pain Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Narayan RK; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.
J Neurosci Res ; 98(12): 2376-2383, 2020 12.
Article in English | MEDLINE | ID: covidwho-738348
ABSTRACT
Manifestation of neurological symptoms in certain patients of coronavirus disease-2019 (COVID-19) has warranted for their virus-induced etiogenesis. SARS-CoV-2, the causative agent of COVID-19, belongs to the genus of betacoronaviruses which also includes SARS-CoV-1 and MERS-CoV; causative agents for severe acute respiratory syndrome (SARS) in 2002 and Middle East respiratory syndrome (MERS) in 2012, respectively. Studies demonstrating the neural invasion of SARS-CoV-2 in vivo are still scarce, although such characteristics of certain other betacoronaviruses are well demonstrated in the literature. Based on the recent evidence for the presence of SARS-CoV-2 host cell entry receptors in specific components of the human nervous and vascular tissue, a neural (olfactory and/or vagal), and a hematogenous-crossing the blood-brain barrier, routes have been proposed. The neurological symptoms in COVID-19 may also arise as a consequence of the "cytokine storm" (characteristically present in severe disease) induced neuroinflammation, or co-morbidities. There is also a possibility that, there may be multiple routes of SARS-CoV-2 entry into the brain, or multiple mechanisms can be involved in the pathogenesis of the neurological symptoms. In this review article, we have discussed the possible routes of SARS-CoV-2 brain entry based on the emerging evidence for this virus, and that available for other betacoronaviruses in literature.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Olfactory Nerve / Pneumonia, Viral / Brain / Blood-Brain Barrier / Coronavirus Infections / Betacoronavirus / Nervous System Diseases Topics: Long Covid Limits: Animals / Humans Language: English Journal: J Neurosci Res Year: 2020 Document Type: Article Affiliation country: Jnr.24717

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Olfactory Nerve / Pneumonia, Viral / Brain / Blood-Brain Barrier / Coronavirus Infections / Betacoronavirus / Nervous System Diseases Topics: Long Covid Limits: Animals / Humans Language: English Journal: J Neurosci Res Year: 2020 Document Type: Article Affiliation country: Jnr.24717