SARS-CoV-2 infection: diagnostic testing results occasionally require special attention.

Riva, Elisabetta; Sainaghi, Pier Paolo; Turriziani, Ombretta; Antonelli, Guido; Patti, Giuseppe

Riva, Elisabetta; Sainaghi, Pier Paolo; Turriziani, Ombretta; Antonelli, Guido; Patti, Giuseppe.

Riva E; Virology Unit, Campus Bio-Medico University of Rome, Rome, Italy.
Sainaghi PP; Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
Turriziani O; Microbiology and Virology Section, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Antonelli G; Microbiology and Virology Section, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Patti G; Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.

Emerg Microbes Infect ; 9(1): 1955-1957, 2020 Dec.

Article in English | MEDLINE | ID: covidwho-738798

ABSTRACT

ABSTRACT

The case refers to a 51-year-old symptomatic man with a new SARS-CoV-2 RNA positive nasopharyngeal swab after two negative ones and the lack of significant development of antibody response measured by different diagnostic serological test. Our case underlines that a discrepancy between clinical course of SARS-CoV-2 infection and results from diagnostic tests may exist. This concept is rapidly emerging and supports the need for a deep knowledge of available and "in development" tests for a correct interpretation of their findings.

Subject(s)

Antibodies, Viral/blood; Betacoronavirus/immunology; Betacoronavirus/isolation & purification; Coronavirus Infections/diagnosis; Immunoglobulin G/blood; Pneumonia, Viral/diagnosis; COVID-19; Coronavirus Infections/drug therapy; Enzyme-Linked Immunosorbent Assay; False Negative Reactions; Humans; Hydroxychloroquine/therapeutic use; Male; Middle Aged; Pandemics; Pneumonia, Viral/drug therapy; Polymerase Chain Reaction; Quarantine; Recurrence; SARS-CoV-2; Serologic Tests; Viral Load

Keywords

SARS-CoV-2 infection; SARS-CoV-2 molecular tests; SARS-CoV-2 serological tests; diagnostic tests; lack of antibodies

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Immunoglobulin G / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Case report / Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Journal: Emerg Microbes Infect Year: 2020 Document Type: Article Affiliation country: 22221751.2020.1814165

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