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Retrospective analysis of clinical characteristics of 405 patients with COVID-19.
Zhan, Ting; Liu, Meng; Tang, Yalin; Han, Zheng; Cheng, Xueting; Deng, Junsheng; Chen, Xiaoli; Tian, Xia; Huang, Xiaodong.
  • Zhan T; Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
  • Liu M; Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
  • Tang Y; Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
  • Han Z; Jianghan University, Wuhan, China.
  • Cheng X; Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
  • Deng J; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Chen X; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Tian X; Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
  • Huang X; Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
J Int Med Res ; 48(8): 300060520949039, 2020 Aug.
Article in English | MEDLINE | ID: covidwho-739220
ABSTRACT

OBJECTIVE:

This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

METHODS:

We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan.

RESULTS:

The patients' median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels.

CONCLUSION:

SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Gastrointestinal Diseases Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: J Int Med Res Year: 2020 Document Type: Article Affiliation country: 0300060520949039

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Gastrointestinal Diseases Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: J Int Med Res Year: 2020 Document Type: Article Affiliation country: 0300060520949039