COVID-19 and Microvascular Disease: Pathophysiology of SARS-CoV-2 Infection With Focus on the Renin-Angiotensin System.
Heart Lung Circ
; 29(11): 1596-1602, 2020 Nov.
Article
in English
| MEDLINE | ID: covidwho-739826
ABSTRACT
The recently described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people, with thousands of fatalities. It has prompted global efforts in research, with focus on the pathophysiology of coronavirus disease-19 (COVID-19), and a rapid surge of publications. COVID-19 has been associated with a myriad of clinical manifestations, including the lungs, heart, kidneys, central nervous system, gastrointestinal system, skin, and blood coagulation abnormalities. The endothelium plays a key role in organ dysfunction associated with severe infection, and current data suggest that it is also involved in SARS-CoV-2-induced sepsis. This critical review aimed to address a possible unifying mechanism underlying the diverse complications of COVID-19 microvascular dysfunction, with emphasis on the renin-angiotensin system. In addition, research perspectives are suggested in order to expand understanding of the pathophysiology of the infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Renin-Angiotensin System
/
Coronavirus Infections
/
Microvessels
/
Pandemics
Type of study:
Prognostic study
/
Reviews
Limits:
Humans
Language:
English
Journal:
Heart Lung Circ
Journal subject:
Vascular Diseases
/
Cardiology
Year:
2020
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS