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COVID-19 and Microvascular Disease: Pathophysiology of SARS-CoV-2 Infection With Focus on the Renin-Angiotensin System.
Kasal, Daniel Arthur; De Lorenzo, Andrea; Tibiriçá, Eduardo.
  • Kasal DA; National Institute of Cardiology, Ministry of Health, Rio de Janeiro, Brazil; State University of Rio de Janeiro, Internal Medicine Department, Rio de Janeiro, Brazil. Electronic address: dabkasal@gmail.com.
  • De Lorenzo A; National Institute of Cardiology, Ministry of Health, Rio de Janeiro, Brazil.
  • Tibiriçá E; National Institute of Cardiology, Ministry of Health, Rio de Janeiro, Brazil.
Heart Lung Circ ; 29(11): 1596-1602, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-739826
ABSTRACT
The recently described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people, with thousands of fatalities. It has prompted global efforts in research, with focus on the pathophysiology of coronavirus disease-19 (COVID-19), and a rapid surge of publications. COVID-19 has been associated with a myriad of clinical manifestations, including the lungs, heart, kidneys, central nervous system, gastrointestinal system, skin, and blood coagulation abnormalities. The endothelium plays a key role in organ dysfunction associated with severe infection, and current data suggest that it is also involved in SARS-CoV-2-induced sepsis. This critical review aimed to address a possible unifying mechanism underlying the diverse complications of COVID-19 microvascular dysfunction, with emphasis on the renin-angiotensin system. In addition, research perspectives are suggested in order to expand understanding of the pathophysiology of the infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Renin-Angiotensin System / Coronavirus Infections / Microvessels / Pandemics Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Heart Lung Circ Journal subject: Vascular Diseases / Cardiology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Renin-Angiotensin System / Coronavirus Infections / Microvessels / Pandemics Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Heart Lung Circ Journal subject: Vascular Diseases / Cardiology Year: 2020 Document Type: Article