Your browser doesn't support javascript.
Serological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreak.
Dingens, Adam S; Crawford, Katharine H D; Adler, Amanda; Steele, Sarah L; Lacombe, Kirsten; Eguia, Rachel; Amanat, Fatima; Walls, Alexandra C; Wolf, Caitlin R; Murphy, Michael; Pettie, Deleah; Carter, Lauren; Qin, Xuan; King, Neil P; Veesler, David; Krammer, Florian; Dickerson, Jane A; Chu, Helen Y; Englund, Janet A; Bloom, Jesse D.
  • Dingens AS; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
  • Crawford KHD; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
  • Adler A; Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.
  • Steele SL; Medical Scientist Training Program, University of Washington, Seattle, WA, 98195, USA.
  • Lacombe K; Division of Infectious Disease, Seattle Children's Hospital, Seattle, WA, 98105, USA.
  • Eguia R; Division of Infectious Disease, Seattle Children's Hospital, Seattle, WA, 98105, USA.
  • Amanat F; Division of Infectious Disease, Seattle Children's Hospital, Seattle, WA, 98105, USA.
  • Walls AC; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
  • Wolf CR; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Murphy M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Pettie D; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
  • Carter L; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, 98195, USA.
  • Qin X; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • King NP; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Veesler D; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Krammer F; Division of Infectious Disease, Seattle Children's Hospital, Seattle, WA, 98105, USA.
  • Dickerson JA; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
  • Chu HY; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Englund JA; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
  • Bloom JD; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Nat Commun ; 11(1): 4378, 2020 09 01.
Article in English | MEDLINE | ID: covidwho-740036
ABSTRACT
Children are strikingly underrepresented in COVID-19 case counts. In the United States, children represent 22% of the population but only 1.7% of confirmed SARS-CoV-2 cases as of April 2, 2020. One possibility is that symptom-based viral testing is less likely to identify infected children, since they often experience milder disease than adults. Here, to better assess the frequency of pediatric SARS-CoV-2 infection, we serologically screen 1,775 residual samples from Seattle Children's Hospital collected from 1,076 children seeking medical care during March and April of 2020. Only one child was seropositive in March, but seven were seropositive in April for a period seroprevalence of ≈1%. Most seropositive children (6/8) were not suspected of having had COVID-19. The sera of seropositive children have neutralizing activity, including one that neutralized at a dilution > 118,000. Therefore, an increasing number of children seeking medical care were infected by SARS-CoV-2 during the early Seattle outbreak despite few positive viral tests.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Visitors to Patients / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: North America Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-18178-1

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Visitors to Patients / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: North America Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-18178-1