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Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU.
Sharifipour, Ehsan; Shams, Saeed; Esmkhani, Mohammad; Khodadadi, Javad; Fotouhi-Ardakani, Reza; Koohpaei, Alireza; Doosti, Zahra; Ej Golzari, Samad.
  • Sharifipour E; Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran.
  • Shams S; Cellular and Molecular Research Center, Faculty of Medicine, Pardis Campus, Qom University of Medical Sciences, Qom, Iran. sshamsmed@gmail.com.
  • Esmkhani M; Ali Ebne Abitaleb Hospital, Qom, Iran.
  • Khodadadi J; Department of Infectious Diseases, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
  • Fotouhi-Ardakani R; Cellular and Molecular Research Center, Faculty of Medicine, Pardis Campus, Qom University of Medical Sciences, Qom, Iran.
  • Koohpaei A; Department of Medical Biotechnology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
  • Doosti Z; Occupational health & Safety Department, Faculty of Health, Qom University of Medical Sciences, Qom, Iran.
  • Ej Golzari S; Cellular and Molecular Research Center, Faculty of Medicine, Pardis Campus, Qom University of Medical Sciences, Qom, Iran.
BMC Infect Dis ; 20(1): 646, 2020 Sep 01.
Article in English | MEDLINE | ID: covidwho-740368
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Bacterial Infections PROCESS_OF Patients
Subject
Bacterial Infections
Predicate
PROCESS_OF
Object
Patients
3. Superinfection PROCESS_OF Patients
Subject
Superinfection
Predicate
PROCESS_OF
Object
Patients
4. Isolate - microorganism PART_OF Staphylococcus aureus
Subject
Isolate - microorganism
Predicate
PART_OF
Object
Staphylococcus aureus
5. Superinfection PROCESS_OF Staphylococcus aureus
Subject
Superinfection
Predicate
PROCESS_OF
Object
Staphylococcus aureus
6. Superinfection PROCESS_OF Acinetobacter calcoaceticus
Subject
Superinfection
Predicate
PROCESS_OF
Object
Acinetobacter calcoaceticus
7. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
8. Bacterial Infections PROCESS_OF Patients
Subject
Bacterial Infections
Predicate
PROCESS_OF
Object
Patients
9. Superinfection PROCESS_OF Patients
Subject
Superinfection
Predicate
PROCESS_OF
Object
Patients
10. Isolate - microorganism PART_OF Staphylococcus aureus
Subject
Isolate - microorganism
Predicate
PART_OF
Object
Staphylococcus aureus
11. Superinfection PROCESS_OF Staphylococcus aureus
Subject
Superinfection
Predicate
PROCESS_OF
Object
Staphylococcus aureus
12. Superinfection PROCESS_OF Acinetobacter calcoaceticus
Subject
Superinfection
Predicate
PROCESS_OF
Object
Acinetobacter calcoaceticus
ABSTRACT

BACKGROUND:

COVID-19 is known as a new viral infection. Viral-bacterial co-infections are one of the biggest medical concerns, resulting in increased mortality rates. To date, few studies have investigated bacterial superinfections in COVID-19 patients. Hence, we designed the current study on COVID-19 patients admitted to ICUs.

METHODS:

Nineteen patients admitted to our ICUs were enrolled in this study. To detect COVID-19, reverse transcription real-time polymerase chain reaction was performed. Endotracheal aspirate samples were also collected and cultured on different media to support the growth of the bacteria. After incubation, formed colonies on the media were identified using Gram staining and other biochemical tests. Antimicrobial susceptibility testing was carried out based on the CLSI recommendations.

RESULTS:

Of nineteen COVID-19 patients, 11 (58%) patients were male and 8 (42%) were female, with a mean age of ~ 67 years old. The average ICU length of stay was ~ 15 days and at the end of the study, 18 cases (95%) expired and only was 1 case (5%) discharged. In total, all patients were found positive for bacterial infections, including seventeen Acinetobacter baumannii (90%) and two Staphylococcus aureus (10%) strains. There was no difference in the bacteria species detected in any of the sampling points. Seventeen of 17 strains of Acinetobacter baumannii were resistant to the evaluated antibiotics. No metallo-beta-lactamases -producing Acinetobacter baumannii strain was found. One of the Staphylococcus aureus isolates was detected as methicillin-resistant Staphylococcus aureus and isolated from the patient who died, while another Staphylococcus aureus strain was susceptible to tested drugs and identified as methicillin-sensitive Staphylococcus aureus.

CONCLUSIONS:

Our findings emphasize the concern of superinfection in COVID-19 patients due to Acinetobacter baumannii and Staphylococcus aureus. Consequently, it is important to pay attention to bacterial co-infections in critical patients positive for COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Staphylococcal Infections / Staphylococcus aureus / Acinetobacter Infections / Coronavirus Infections / Acinetobacter baumannii / Coinfection / Betacoronavirus Type of study: Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: S12879-020-05374-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Staphylococcal Infections / Staphylococcus aureus / Acinetobacter Infections / Coronavirus Infections / Acinetobacter baumannii / Coinfection / Betacoronavirus Type of study: Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: S12879-020-05374-z