Case Report: Adrenal Pathology Findings in Severe COVID-19: An Autopsy Study.
Am J Trop Med Hyg
; 103(4): 1604-1607, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-914664
ABSTRACT
Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings in the adrenal glands in 28 autopsies with confirmed SARS-CoV-2 infection. Microscopic lesions were identified in the adrenal glands in 12/28 patients (46%). Seven cases showed necrosis, generally ischemic; four showed cortical lipid degeneration; two showed hemorrhage; and one unspecific focal adrenalitis. Vascular thrombosis in one patient and focal inflammation in association with other findings in three patients were observed. No case presented adrenal insufficiency. In conclusion, adrenal lesions are frequent in patients with severe COVID-19. The lesions are mild but could contribute to the lethal outcome.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Autopsy
/
Adrenal Glands
/
Coronavirus Infections
/
Betacoronavirus
Type of study:
Case report
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Am J Trop Med Hyg
Year:
2020
Document Type:
Article
Affiliation country:
Ajtmh.20-0787
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