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Outcome of early-stage combination treatment with favipiravir and methylprednisolone for severe COVID-19 pneumonia: A report of 11 cases.
Murohashi, Kota; Hagiwara, Eri; Kitayama, Takaaki; Yamaya, Takafumi; Higa, Katsuyuki; Sato, Yozo; Otoshi, Ryota; Shintani, Ryota; Okabayashi, Hiroko; Ikeda, Satoshi; Niwa, Takashi; Nakazawa, Atsuhito; Oda, Tsuneyuki; Okuda, Ryo; Sekine, Akimasa; Kitamura, Hideya; Baba, Tomohisa; Komatsu, Shigeru; Iwasawa, Tae; Kaneko, Takeshi; Ogura, Takashi.
  • Murohashi K; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan; Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Hagiwara E; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Kitayama T; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Yamaya T; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Higa K; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Sato Y; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Otoshi R; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Shintani R; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Okabayashi H; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Ikeda S; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Niwa T; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Nakazawa A; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Oda T; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Okuda R; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Sekine A; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Kitamura H; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Baba T; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Komatsu S; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Iwasawa T; Department of Radiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
  • Kaneko T; Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Ogura T; Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan. Electronic address: ogura@kanagawa-junko.jp.
Respir Investig ; 58(6): 430-434, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-741469
ABSTRACT
Although the use of corticosteroids is not recommended in the World Health Organization statement for the treatment of coronavirus disease 2019 (COVID-19), steroid therapy may be indicated for critical cases in specific situations. Here, we report the successful treatment of 11 cases of severe COVID-19 pneumonia with favipiravir and methylprednisolone. All cases were severe and patients required oxygen administration or had a blood oxygen saturation ≤93% on room air. All were treated with favipiravir and methylprednisolone, and 10 of 11 patients responded well and required no further oxygen supplementation or ventilator management. This study shows the importance of the early-stage use of a combination of favipiravir and methylprednisolone in severe cases to achieve a favorable clinical outcome.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Methylprednisolone / COVID-19 Type of study: Case report / Prognostic study Limits: Humans Language: English Journal: Respir Investig Year: 2020 Document Type: Article Affiliation country: J.resinv.2020.08.001

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Methylprednisolone / COVID-19 Type of study: Case report / Prognostic study Limits: Humans Language: English Journal: Respir Investig Year: 2020 Document Type: Article Affiliation country: J.resinv.2020.08.001