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Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1.
Sierra, Beatriz; Pérez, Ana B; Aguirre, Eglis; Bracho, Claudia; Valdés, Odalys; Jimenez, Narciso; Baldoquin, Waldemar; Gonzalez, Guelsys; Ortega, Lilia M; Montalvo, Maria C; Resik, Sonia; Alvarez, Delmis; Guzmán, Maria G.
  • Sierra B; Cellular Immunology Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Pérez AB; Cellular Immunology Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Aguirre E; Cellular Immunology Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Bracho C; Cellular Immunology Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Valdés O; Respiratory Viruses Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Jimenez N; Medical Attention Branch, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Baldoquin W; Epidemiology Department Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Gonzalez G; Respiratory Viruses Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Ortega LM; Intensive Care Unit, Medical Attention Branch, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Montalvo MC; Hepatitis Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Resik S; Enterovirus Laboratory, Virology Department, Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Alvarez D; Department of Computing, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
  • Guzmán MG; Center for Research, Diagnostic and Reference, Pedro Kourí Institute of Tropical Medicine, Havana, Cuba.
Open Forum Infect Dis ; 7(10): ofaa407, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-741905
ABSTRACT
Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19's pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2020 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2020 Document Type: Article Affiliation country: Ofid