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Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome.
Diorio, Caroline; Anderson, Elizabeth M; McNerney, Kevin O; Goodwin, Eileen C; Chase, Julie C; Bolton, Marcus J; Arevalo, Claudia P; Weirick, Madison E; Gouma, Sigrid; Vella, Laura A; Henrickson, Sarah E; Chiotos, Kathleen; Fitzgerald, Julie C; Kilbaugh, Todd J; John, Audrey R Odom; Blatz, Allison M; Lambert, Michele P; Sullivan, Kathleen E; Tartaglione, Margaret R; Zambrano, Danielle; Martin, Meghan; Lee, Jessica H; Young, Pampee; Friedman, David; Sesok-Pizzini, Deborah A; Hensley, Scott E; Behrens, Edward M; Bassiri, Hamid; Teachey, David T.
  • Diorio C; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Anderson EM; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • McNerney KO; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Goodwin EC; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Chase JC; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Bolton MJ; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Arevalo CP; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Weirick ME; Division of Rheumatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Gouma S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Vella LA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Henrickson SE; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Chiotos K; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Fitzgerald JC; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Kilbaugh TJ; Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • John ARO; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Blatz AM; Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Lambert MP; Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Sullivan KE; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Tartaglione MR; Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Zambrano D; Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Martin M; Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Lee JH; Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Young P; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Friedman D; Division of Hematology, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Sesok-Pizzini DA; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Hensley SE; Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Behrens EM; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Bassiri H; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Teachey DT; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Pediatr Blood Cancer ; 67(11): e28693, 2020 11.
Article in English | MEDLINE | ID: covidwho-743696
Semantic information from SemMedBD (by NLM)
1. Respiratory Distress Syndrom PROCESS_OF C0030705
Subject
Respiratory Distress Syndrom
Predicate
PROCESS_OF
Object
C0030705
2. Therapeutic procedure TREATS Complication
Subject
Therapeutic procedure
Predicate
TREATS
Object
Complication
3. Therapeutic procedure TREATS Child
Subject
Therapeutic procedure
Predicate
TREATS
Object
Child
4. Complication PROCESS_OF Child
Subject
Complication
Predicate
PROCESS_OF
Object
Child
5. Patients LOCATION_OF Plasma
Subject
Patients
Predicate
LOCATION_OF
Object
Plasma
6. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
7. Child LOCATION_OF Plasma
Subject
Child
Predicate
LOCATION_OF
Object
Plasma
8. 2019 novel coronavirus PROCESS_OF Adult
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Adult
9. Adult LOCATION_OF Plasma
Subject
Adult
Predicate
LOCATION_OF
Object
Plasma
10. Antibody Formation PROCESS_OF Recipient
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Recipient
11. Respiratory Distress Syndrome, Adult PROCESS_OF Patients
Subject
Respiratory Distress Syndrome, Adult
Predicate
PROCESS_OF
Object
Patients
12. Therapeutic procedure TREATS Complication
Subject
Therapeutic procedure
Predicate
TREATS
Object
Complication
13. Therapeutic procedure TREATS Child
Subject
Therapeutic procedure
Predicate
TREATS
Object
Child
14. Complication PROCESS_OF Child
Subject
Complication
Predicate
PROCESS_OF
Object
Child
15. Patients LOCATION_OF Plasma
Subject
Patients
Predicate
LOCATION_OF
Object
Plasma
16. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
17. Child LOCATION_OF Plasma
Subject
Child
Predicate
LOCATION_OF
Object
Plasma
18. 2019 novel coronavirus PROCESS_OF Adult
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Adult
19. Adult LOCATION_OF Plasma
Subject
Adult
Predicate
LOCATION_OF
Object
Plasma
20. Antibody Formation PROCESS_OF Recipient
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Recipient
ABSTRACT
There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the first report of CP in children with life-threatening coronavirus disease 2019 (COVID-19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody-dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. Randomized pediatric trials are needed.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 Type of study: Controlled clinical trial / Etiology study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adolescent / Humans Language: English Journal: Pediatr Blood Cancer Journal subject: Hematology / Neoplasms / Pediatrics Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 Type of study: Controlled clinical trial / Etiology study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adolescent / Humans Language: English Journal: Pediatr Blood Cancer Journal subject: Hematology / Neoplasms / Pediatrics Year: 2020 Document Type: Article