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Coronavirus 2019, Microthromboses, and Platelet Activating Factor.
Theoharides, Theoharis C; Antonopoulou, Smaragdi; Demopoulos, Constantinos A.
  • Theoharides TC; Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA; School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA; Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA. Electronic address: theoharis.theoharides@tufts.edu.
  • Antonopoulou S; Laboratory of Biology, Biochemistry and Microbiology, Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
  • Demopoulos CA; Laboratory of Biochemistry, Faculty of Chemistry, National & Kapodistrian University of Athens, Athens, Greece.
Clin Ther ; 42(10): 1850-1852, 2020 10.
Article in English | MEDLINE | ID: covidwho-743922
ABSTRACT
Recent articles have reported elevated markers of coagulation, endothelial injury, and microthromboses in lungs from deceased patients with coronavirus 2019 (COVID-19). Platelets are critical in the formation of thrombi, and their most potent trigger is platelet activating factor (PAF). PAF is produced by cells involved in host defense, and its biological actions bear similarities with COVID-19 disease manifestations, including pulmonary microthromboses and inflammation, possibly via activation of mast cells. The histamine1 receptor antagonist rupatadine was developed to have anti-PAF activity and inhibits activation of human mast cells in response to PAF. Rupatadine could be repurposed for COVID-19 prophylaxis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thrombosis / Platelet Activating Factor / Coronavirus Infections / Pandemics Limits: Humans Language: English Journal: Clin Ther Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thrombosis / Platelet Activating Factor / Coronavirus Infections / Pandemics Limits: Humans Language: English Journal: Clin Ther Year: 2020 Document Type: Article