Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.
J Exp Med
; 217(12)2020 12 07.
Article
in English
| MEDLINE | ID: covidwho-744478
ABSTRACT
COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS-CoV-2-driven ARDS.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Phenotype
/
Pneumonia, Viral
/
Respiratory Distress Syndrome
/
Receptors, Antigen, T-Cell, gamma-delta
/
Coronavirus Infections
/
Natural Killer T-Cells
/
Mucosal-Associated Invariant T Cells
/
Betacoronavirus
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Year:
2020
Document Type:
Article
Affiliation country:
Jem.20200872
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