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COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?
Jakovac, Hrvoje.
  • Jakovac H; Medical Faculty, Department of Physiology and Immunology, University of Rijeka, Rijeka, Croatia.
Am J Physiol Heart Circ Physiol ; 319(4): H793-H796, 2020 10 01.
Article in English | MEDLINE | ID: covidwho-744896
ABSTRACT
The 60-kDa heat shock protein (HSP60) is a chaperone essential for mitochondrial proteostasis ensuring thus sufficient aerobic energy production. In pathological conditions, HSP60 can be translocated from the mitochondria and excreted from the cell. In turn, the extracellular HSP60 has a strong ability to trigger and enhance inflammatory response with marked proinflammatory cytokine induction, which is mainly mediated by Toll-like receptor binding. Previous studies have found increased circulating levels of HSP60 in hypertensive patients, as well as enhanced HSP60 expression and membrane translocation in the hypertrophic myocardium. These observations are of particular interest, since they could provide a possible pathophysiological explanation of the severe course and worse outcome of severe acute respiratory syndrome coronavirus 2 infection in hypertensive patients, repeatedly reported during the recent coronavirus disease 2019 (COVID-19) pandemic and related to hyperinflammatory response and cytokine storm development during the third phase of the disease. In this regard, pharmacological inhibition of HSP60 could attract attention to potentially ameliorate inappropriate inflammatory reaction in severe COVID-19 patients. Among HSP60 antagonizing drugs, mizoribine is the most intriguing, since it is clinically approved and exerts antiviral activity. However, this topic requires to be further scrutinized.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Inflammation Mediators / Chaperonin 60 / Betacoronavirus / Hypertension Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Am J Physiol Heart Circ Physiol Journal subject: Cardiology / Physiology Year: 2020 Document Type: Article Affiliation country: Ajpheart.00506.2020

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Inflammation Mediators / Chaperonin 60 / Betacoronavirus / Hypertension Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Am J Physiol Heart Circ Physiol Journal subject: Cardiology / Physiology Year: 2020 Document Type: Article Affiliation country: Ajpheart.00506.2020