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Methodological Issues and Controversies in COVID-19 Coagulopathy: A Tale of Two Storms.
Berkman, Samuel A; Tapson, Victor F.
  • Berkman SA; Department of Medicine.
  • Tapson VF; Cedars-Sinai Medical Center Los Angeles, CA, USA.
Clin Appl Thromb Hemost ; 26: 1076029620945398, 2020.
Article in English | MEDLINE | ID: covidwho-744937
ABSTRACT
Venous thromboembolism, occlusion of dialysis catheters, circuit thrombosis in ECMO devices, all in the face of prophylactic and sometimes even therapeutic anti-coagulation, are frequent features of COVID-19 coagulopathy. The trials available to guide clinicians are methodologically limited. There are several unresolved controversies including 1) Should all hospitalized patients with COVID-19 receive prophylactic anti-coagulation? 2) Which patients should have their dosage escalated to intermediate dose? 3) Which patients should be considered for full-dose anti-coagulation even without a measurable thromboembolic event and how should that anti-coagulation be monitored? 4) Should patients receive post-discharge anti-coagulation? 5) What thrombotic issues are related to the various medications being used to treat this coagulopathy? 6) Is anti-phospholipid anti-body part of this syndrome? 7) How do the different treatments for this disease impact the coagulation issues? The aims of this article are to explore these questions and interpret the available data based on the current evidence.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Coagulation Disorders / Fibrin Fibrinogen Degradation Products / Coronavirus Infections / Venous Thromboembolism / Anticoagulants Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Coagulation Disorders / Fibrin Fibrinogen Degradation Products / Coronavirus Infections / Venous Thromboembolism / Anticoagulants Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2020 Document Type: Article