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Coronavirus disease 2019 infection in patients with recent cardiac surgery: does chronic anticoagulant therapy have a protective effect?
Inama, Giuseppe; Dodi, Claudio; Provini, Martino; Bossoni, Enzo; Inama, Lorenza; Balzarini, Laura; Mancini, Chiara; Ramponi, Sara; Marvisi, Maurizio.
  • Inama G; Division of Cardiology and Cardiac Rehabilitation, Istituto Figlie di San Camillo, Cremona.
  • Dodi C; Division of Cardiology and Cardiac Rehabilitation, Istituto Figlie di San Camillo, Cremona.
  • Provini M; Division of Cardiology and Cardiac Rehabilitation, Istituto Figlie di San Camillo, Cremona.
  • Bossoni E; Division of Cardiology and Cardiac Rehabilitation, Istituto Figlie di San Camillo, Cremona.
  • Inama L; Division of Cardiology, ASST del Garda, Ospedale di Manerbio.
  • Balzarini L; Division of Internal Medicine and Respiratory Rehabilitation, Istituto Figlie di San Camillo, Cremona, Italy.
  • Mancini C; Division of Internal Medicine and Respiratory Rehabilitation, Istituto Figlie di San Camillo, Cremona, Italy.
  • Ramponi S; Division of Internal Medicine and Respiratory Rehabilitation, Istituto Figlie di San Camillo, Cremona, Italy.
  • Marvisi M; Division of Internal Medicine and Respiratory Rehabilitation, Istituto Figlie di San Camillo, Cremona, Italy.
J Cardiovasc Med (Hagerstown) ; 21(10): 765-771, 2020 10.
Article in English | MEDLINE | ID: covidwho-745112
ABSTRACT

AIMS:

The aim of this study was to evaluate the clinical course of COVID-19 in patients who had recently undergone a cardiac procedure and were inpatients in a cardiac rehabilitation department.

METHODS:

All patients hospitalized from 1 February to 15 March 2020 were included in the study (n = 35; 16 men; mean age 78 years). The overall population was divided into two groups group 1 included 10 patients who presented with a clinical picture of COVID-19 infection and were isolated, and group 2 included 25 patients who were COVID-19-negative. In group 1, nine patients were on chronic oral anticoagulant therapy and one patient was on acetylsalicylic acid (ASA) and clopidogrel. A chest computed tomography scan revealed interstitial pneumonia in all 10 patients.

RESULTS:

During hospitalization, COVID-19 patients received azithromycin and hydroxychloroquine in addition to their ongoing therapy. Only the patient on ASA with clopidogrel therapy was transferred to the ICU for mechanical ventilation because of worsening respiratory failure, and subsequently died from cardiorespiratory arrest. All other patients on chronic anticoagulant therapy recovered and were discharged.

CONCLUSION:

Our study suggests that COVID-19 patients on chronic anticoagulant therapy may have a more favorable and less complicated clinical course. Further prospective studies are warranted to confirm this preliminary observation.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Postoperative Complications / Platelet Aggregation Inhibitors / Coronavirus Infections / Azithromycin / Pandemics / Cardiac Surgical Procedures / Hydroxychloroquine / Anticoagulants Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male Language: English Journal: J Cardiovasc Med (Hagerstown) Journal subject: Vascular Diseases / Cardiology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Postoperative Complications / Platelet Aggregation Inhibitors / Coronavirus Infections / Azithromycin / Pandemics / Cardiac Surgical Procedures / Hydroxychloroquine / Anticoagulants Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male Language: English Journal: J Cardiovasc Med (Hagerstown) Journal subject: Vascular Diseases / Cardiology Year: 2020 Document Type: Article