Genomic evolution of severe acute respiratory syndrome Coronavirus 2 in India and vaccine impact.
Indian J Med Microbiol
; 38(2): 210-212, 2020.
Article
in English
| MEDLINE | ID: covidwho-745217
ABSTRACT
Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this virus. We have analysed genome sequences of SARS-CoV-2 isolated from Indian patients to gain an in-depth understanding of genomic evolution and transmission in India. Phylogenetic analysis and mutation profiling revealed major lineages being evolved by characteristic mutations. As the mutation frequency in spike protein is comparatively lesser, the candidate vaccines expected to have wide coverage worldwide including India.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Viral Vaccines
/
Genome, Viral
/
Coronavirus Infections
/
Pandemics
/
Spike Glycoprotein, Coronavirus
/
Betacoronavirus
/
Antigens, Viral
Type of study:
Experimental Studies
/
Observational study
/
Randomized controlled trials
Topics:
Vaccines
Limits:
Animals
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2020
Document Type:
Article
Affiliation country:
Ijmm.IJMM_20_303
Similar
MEDLINE
...
LILACS
LIS