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Relation between blood glucose and the prognosis of severe coronavirus disease 2019. / 血糖与重型2019冠状病毒病预后的关系.
Liu, Zuoliang; Liu, Shengping; Wang, Zhifei; Liu, Chun; Long, Feiyan; Jin, Ping.
  • Liu Z; Department of Critical Care Medicine, Third Xiangya Hospital, Central South University, Changsha 410013. 296574022@qq.com.
  • Liu S; Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013.
  • Wang Z; Department of Neurosurgery, Third Xiangya Hospital, Central South University, Changsha 410013.
  • Liu C; Department of Respiratory Disease, Third Xiangya Hospital, Central South University, Changsha 410013, China.
  • Long F; Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013.
  • Jin P; Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013. jping7676@hotmail.com.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 45(5): 530-535, 2020 May 28.
Article in English, Chinese | MEDLINE | ID: covidwho-745312
ABSTRACT

OBJECTIVES:

To describe the clinical characteristics and outcomes of severely ill patients with coronavirus disease 2019, and to investigate the relationship between plasma glucose level and the prognosis of severely ill patients with coronavirus disease 2019.

METHODS:

We enrolled 52 severely ill patients with coronavirus disease 2019. Among them, 12 cases progressed to critical illness. The clinical and biochemical characteristics of severely and critically ill patients were compared.

RESULTS:

Compared with the severely ill patients, critically ill patients had higher white blood cell and neutrophil counts, as well as higher levels of D-dimer, IL-6 and C-reactive protein (all P<0.05). Before treatment, the fasting plasma glucose (FPG) levels were significantly higher in the critically ill patient's group [(10.23±3.71) mmol/L] compared to those in the severely ill patients [(7.12±3.35) mmol/L, P<0.05]. After adjusting for age, gender, and course of the disease, fasting blood glucose at admission (OR=1.308, 95% CI 1.066 to 1.606, P=0.01) and hyperglycemia at admission (OR=29.198, 95% CI 2.903 to 293.639, P=0.004) were closely related to whether severely ill patients progressed to critical patients with coronavirus disease 2019. In our study, 15 (34.8%) of the severely ill and 10 (83.3%) critically ill patients received the steroid treatment. Compared with the severely ill patients, the FPG levels in critically ill patients were higher (P<0.05).

CONCLUSIONS:

Fasting hyperglycemia at admission is a significant predictor for the prognosis of severely ill patients with coronavirus disease 2019. Closely monitoring and the optimal management of hyperglycemia may improve the prognosis of patients with coronavirus disease 2019.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Glucose / Coronavirus Infections / Hyperglycemia Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English / Chinese Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban Journal subject: Medicine Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Glucose / Coronavirus Infections / Hyperglycemia Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English / Chinese Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban Journal subject: Medicine Year: 2020 Document Type: Article