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Effect of transfusion convalescent recovery plasma in patients with coronavirus disease 2019. / 2019冠状病毒病患者输注康复者恢复期血浆疗效.
Xiao, Kun; Lin, Yang; Fan, Zhifang; Wen, Yuchuan; Huang, Huiqing; Wang, Min; Ren, Dequan; Wu, Chenggao; Liu, Wei; Zhang, Zhanglin; Li, Guoliang; LE, Aiping.
  • Xiao K; Department of Blood Transfusion, First Affiliated Hospital of Nanchang University, Nanchang 330006. 376069793@qq.com.
  • Lin Y; Department of Respiration, First Affiliated Hospital of Nanchang University, Nanchang 330006.
  • Fan Z; Fuzhou Central Blood Station, Fuzhou Jiangxi 344000.
  • Wen Y; Yichun Central Blood Station, Yichun Jiangxi 336000.
  • Huang H; Jiangxi Province Blood Center, Nanchang 330052.
  • Wang M; Shicheng Shangsheng Single Plasma Collection Ltd, Ganzhou Jiangxi 342700, China.
  • Ren D; Shicheng Shangsheng Single Plasma Collection Ltd, Ganzhou Jiangxi 342700, China.
  • Wu C; Department of Blood Transfusion, First Affiliated Hospital of Nanchang University, Nanchang 330006.
  • Liu W; Department of Blood Transfusion, First Affiliated Hospital of Nanchang University, Nanchang 330006.
  • Zhang Z; Department of Blood Transfusion, First Affiliated Hospital of Nanchang University, Nanchang 330006.
  • Li G; Department of Blood Transfusion, First Affiliated Hospital of Nanchang University, Nanchang 330006.
  • LE A; Department of Blood Transfusion, First Affiliated Hospital of Nanchang University, Nanchang 330006. leaiping@126.com.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 45(5): 565-570, 2020 May 28.
Article in English, Chinese | MEDLINE | ID: covidwho-745332
ABSTRACT

OBJECTIVES:

To evaluate curative effects of coronavirus disease 2019 (COVID-19) patients by the transfusion of other convalescent plasma.

METHODS:

Retrospective analysis of the clinical data of 18 patients with severe and critical COVID-19, who were hospitalized in the ICU of Xianghu Branch of the First Affiliated Hospital of Nanchang University from February 1 to March 15, 2020. Patients were subdivided into an experimental group (n=6, who had transfused the plasma) and an observation group (n=12, who had no plasma transfusion). Basic clinical data and prognosis indexes of these two groups were compared. Moreover, for the experimental group, the dynamic changes of blood oxygen saturation before and after the transfusion, the changes of lymphocyte absolute value 48 hours after the transfusion, and the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid were analyzed.

RESULTS:

There were no significant differences in age, gender, blood type and other basic clinical data between the two groups (all P>0.05).There were no significant differences in ventilator machine weaning time, extracorporeal membrane oxygenation (ECMO) weaning time, body temperature recovery to normal time, and hospitalization days between these two groups (all P>0.05). For the experimental group, before, during and after the convalescent plasma transfusion, the blood oxygen saturation of all 6 patients at all time (1, 6, 8, 12, 24, 36, and 48 h) was more than 90%, and there was no significant fluctuation. There were 3 patients whose absolute value of lymphocyte was increased 48 hours after the transfusion, and the remaining was decreased. There were 5 patients whose SARS-CoV-2 nucleic acid detection turned negative 48 hours after the transfusion, accounting for 83.3%.

CONCLUSIONS:

Transfusion of convalescent plasma will not affect outcomesof COVID-19 patients, which can neutralize SARS-CoV-2 in patients and reduce the loading capacity of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Asia Language: English / Chinese Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban Journal subject: Medicine Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Asia Language: English / Chinese Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban Journal subject: Medicine Year: 2020 Document Type: Article