Association of ACE2 receptor and ACEIs/ARBs with disease severity in COVID-19.
Drug Discov Ther
; 14(4): 161-170, 2020.
Article
in English
| MEDLINE | ID: covidwho-745656
ABSTRACT
Coronavirus disease 2019 (COVID-19) is found to be associated with various comorbidities which include cardiovascular diseases, hypertension, and diabetes. The impaired regulation of renin-angiotensin-aldosterone system (RAAS) has been seen in COVID-19 patients, but whether RAAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are responsible for worsening of clinical conditions remains unknown. Herein, we review the role of angiotensin-converting enzyme 2 (ACE2) expression in disease progression, its association with comorbidities and COVID-19, and summarize the clinical evidence for several potential directions for future research work on ACEIs/ARBs in COVID-19 patients.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Renin-Angiotensin System
/
Coronavirus Infections
/
Peptidyl-Dipeptidase A
/
Virus Internalization
/
Betacoronavirus
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Drug Discov Ther
Year:
2020
Document Type:
Article
Affiliation country:
Ddt.2020.03064
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