Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage During Acute Inflammation.
Chem Res Toxicol
; 33(10): 2668-2674, 2020 10 19.
Article
in English
| MEDLINE | ID: covidwho-745890
ABSTRACT
Inflammation is an immune response to protect against various types of infections. When unchecked, acute inflammation can be life-threatening, as seen with the current coronavirus pandemic. Strong oxidants, such as peroxynitrite produced by immune cells, are major mediators of the inflammation-associated pathogenesis. Cellular thiols play important roles in mitigating inflammation-associated macromolecular damage including DNA. Herein, we have demonstrated a role of glutathione (GSH) and other thiols in neutralizing the effect of peroxynitrite-mediated DNA damage through stable GSH-DNA adduct formation. Our observation supports the use of thiol supplements as a potential therapeutic strategy against severe COVID-19 cases and a Phase II (NCT04374461) open-label clinical trial launched in early May 2020 by the Memorial Sloan Kettering Cancer Center.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
DNA
/
DNA Adducts
/
Peroxynitrous Acid
/
Glutathione
/
Inflammation
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Animals
/
Humans
Language:
English
Journal:
Chem Res Toxicol
Journal subject:
Toxicology
Year:
2020
Document Type:
Article
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