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Acute chest syndrome in the setting of SARS-COV-2 infections-A case series at an urban medical center in the Bronx.
Morrone, Kerry A; Strumph, Kaitlin; Liszewski, Mark J; Jackson, Jenai; Rinke, Michael L; Silver, Ellen J; Minniti, Caterina; Davila, Jennifer; Mitchell, William B; Manwani, Deepa.
  • Morrone KA; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Albert Einstein College of Medicine, New York City, New York.
  • Strumph K; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Albert Einstein College of Medicine, New York City, New York.
  • Liszewski MJ; Department of Radiology, Division of Pediatric Radiology, Albert Einstein College of Medicine, New York City, New York.
  • Jackson J; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Albert Einstein College of Medicine, New York City, New York.
  • Rinke ML; Department of Pediatrics, Division of Academic General Pediatrics, Albert Einstein College of Medicine, New York City, New York.
  • Silver EJ; Department of Pediatrics, Division of Academic General Pediatrics and Montefiore School Health Program, Albert Einstein College of Medicine, New York City, New York.
  • Minniti C; Department of Medicine, Division of Hematology, Albert Einstein College of Medicine, New York City, New York.
  • Davila J; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Albert Einstein College of Medicine, New York City, New York.
  • Mitchell WB; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Albert Einstein College of Medicine, New York City, New York.
  • Manwani D; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Albert Einstein College of Medicine, New York City, New York.
Pediatr Blood Cancer ; 67(11): e28579, 2020 11.
Article in English | MEDLINE | ID: covidwho-746153
ABSTRACT
New York City has emerged as one of the epicenters of the SARS-COV-2 pandemic, with the Bronx being disproportionately affected. This novel coronavirus has caused significant respiratory manifestations raising the concern for development of acute chest syndrome (ACS) in patients with sickle cell disease (SCD). We report a series of pediatric SCD SARS-COV-2-positive patients admitted with ACS. SARS-COV-2-positive SCD patients, who did not develop ACS, were the comparison group. Hydroxyurea use (P-value = .02) and lower absolute monocyte counts (P-value = .04) were noted in patients who did not develop ACS. These preliminary findings need to be further evaluated in larger cohorts.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Chest Syndrome / COVID-19 / Anemia, Sickle Cell Type of study: Case report / Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Child / Female / Humans / Male / Young adult Country/Region as subject: North America Language: English Journal: Pediatr Blood Cancer Journal subject: Hematology / Neoplasms / Pediatrics Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Chest Syndrome / COVID-19 / Anemia, Sickle Cell Type of study: Case report / Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Child / Female / Humans / Male / Young adult Country/Region as subject: North America Language: English Journal: Pediatr Blood Cancer Journal subject: Hematology / Neoplasms / Pediatrics Year: 2020 Document Type: Article