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Curcumin (a constituent of turmeric): New treatment option against COVID-19.
Babaei, Fatemeh; Nassiri-Asl, Marjan; Hosseinzadeh, Hossein.
  • Babaei F; Department of Clinical Biochemistry School of Medicine, Student Research Committee Shahid Beheshti University of Medical Sciences Tehran Iran.
  • Nassiri-Asl M; Department of Pharmacology and Neurobiology Research Center School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.
  • Hosseinzadeh H; Department of Pharmacodynamics and Toxicology School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran.
Food Sci Nutr ; 8(10): 5215-5227, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-746165
ABSTRACT
In late December 2019, the outbreak of respiratory illness emerged in Wuhan, China, and spreads worldwide. World Health Organization (WHO) named this disease severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused by a new member of beta coronaviruses. Several medications are prescribed to patients, and some clinical trials are underway. Scientists are trying to find a specific drug against this virus. In this review, we summarize the pathogenesis, clinical features, and current treatments of coronavirus disease 2019 (COVID-19). Then, we describe the possible therapeutic effects of curcumin and its molecular mechanism against coronavirus-19. Curcumin, as an active constituent of Curcuma longa (turmeric), has been studied in several experimental and clinical trial studies. Curcumin has some useful clinical effects such as antiviral, antinociceptive, anti-inflammatory, antipyretic, and antifatigue effects that could be effective to manage the symptoms of the infected patient with COVID-19. It has several molecular mechanisms including antioxidant, antiapoptotic, and antifibrotic properties with inhibitory effects on Toll-like receptors, NF-κB, inflammatory cytokines and chemokines, and bradykinin. Scientific evidence suggests that curcumin could have a potential role to treat COVID-19. Thus, the use of curcumin in the clinical trial, as a new treatment option, should be considered.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Language: English Journal: Food Sci Nutr Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Language: English Journal: Food Sci Nutr Year: 2020 Document Type: Article