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Neuropathological findings in two patients with fatal COVID-19.
Jensen, M P; Le Quesne, J; Officer-Jones, L; Teodòsio, A; Thaventhiran, J; Ficken, C; Goddard, M; Smith, C; Menon, D; Allinson, K S J.
  • Jensen MP; Barts Health NHS Trust, London, UK.
  • Le Quesne J; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.
  • Officer-Jones L; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
  • Teodòsio A; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.
  • Thaventhiran J; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.
  • Ficken C; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.
  • Goddard M; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.
  • Smith C; Department of Pathology, Royal Papworth Hospital, Cambridge, UK.
  • Menon D; Department of Virology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
  • Allinson KSJ; University Division of Anaesthesia, University of Cambridge, Cambridge, UK.
Neuropathol Appl Neurobiol ; 47(1): 17-25, 2021 02.
Article in English | MEDLINE | ID: covidwho-748744
ABSTRACT

AIMS:

To describe the neuropathological findings in two cases of fatal Coronavirus Disease 2019 (COVID-19) with neurological decline.

METHODS:

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection was confirmed in both patients by reverse transcription polymerase chain reaction (RT-PCR) from nasopharyngeal swabs antemortem. Coronial autopsies were performed on both patients and histological sampling of the brain was undertaken with a variety of histochemical and immunohistochemical stains. RNAscope® in situ hybridization (ISH) using the V-nCoV2019-S probe and RT-PCR SARS-CoV-2 ribonucleic acid (RNA) was performed in paraffin-embedded brain tissue sampled from areas of pathology.

RESULTS:

Case 1 demonstrated severe multifocal cortical infarction with extensive perivascular calcification and numerous megakaryocytes, consistent with a severe multi-territorial cerebral vascular injury. There was associated cerebral thrombotic microangiopathy. Case 2 demonstrated a brainstem encephalitis centred on the dorsal medulla and a subacute regional infarct involving the cerebellar cortex. In both cases, ISH and RT-PCR for SARS-CoV-2 RNA were negative in tissue sampled from the area of pathology.

CONCLUSIONS:

Our case series adds calcifying cerebral cortical infarction with associated megakaryocytes and brainstem encephalitis to the spectrum of neuropathological findings that may contribute to the neurological decompensation seen in some COVID-19 patients. Viral RNA was not detected in post-mortem brain tissue, suggesting that these pathologies may not be a direct consequence of viral neuroinvasion and may represent para-infectious phenomena, relating to the systemic hyperinflammatory and hypercoagulable syndromes that both patients suffered.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Brain Diseases / COVID-19 Type of study: Case report / Prognostic study Limits: Aged / Humans / Male Language: English Journal: Neuropathol Appl Neurobiol Year: 2021 Document Type: Article Affiliation country: Nan.12662

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Brain Diseases / COVID-19 Type of study: Case report / Prognostic study Limits: Aged / Humans / Male Language: English Journal: Neuropathol Appl Neurobiol Year: 2021 Document Type: Article Affiliation country: Nan.12662