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Collapsing Glomerulopathy Affecting Native and Transplant Kidneys in Individuals with COVID-19.
Noble, Rebecca; Tan, Mei Ying; McCulloch, Thomas; Shantier, Mohamed; Byrne, Catherine; Hall, Matthew; Jesky, Mark.
  • Noble R; Nottingham Renal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
  • Tan MY; Nottingham Renal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
  • McCulloch T; Histopathology Department, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
  • Shantier M; Nottingham Renal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
  • Byrne C; Nottingham Renal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
  • Hall M; Nottingham Renal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
  • Jesky M; Nottingham Renal and Transplant Unit, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, mark.jesky@nuh.nhs.uk.
Nephron ; 144(11): 589-594, 2020.
Article in English | MEDLINE | ID: covidwho-748831
ABSTRACT
Since the emergency of novel coronavirus COVID-19 (SARS-CoV-2) in December 2019, infections have spread rapidly across the world. The reported incidence of acute kidney injury (AKI) in the context of COVID-19 is variable, and its mechanism is not well understood. Data are emerging about possible mechanisms of AKI including virus-induced cytopathic effect and cytokine storm-induced injury. To date, there have been few reports of kidney biopsy findings in the context of AKI in COVID-19 infection. This article describes 2 cases of collapsing glomerulopathy, 1 in a native kidney and, for the first time, 1 in a kidney transplant. Both individuals were black, and both presented without significant respiratory compromise. Indeed, the 2 patients we describe remained systemically well for the majority of their inpatient stay, which would support the hypothesis that for these patients, AKI was caused by a cytopathic viral effect, rather than that of a cytokine storm or acute tubular necrosis caused by prolonged hypovolaemia or the effect of medication known to exacerbate AKI. Here, we report 2 cases of AKI with collapsing glomerulopathy in COVID-19, one of which is in a kidney transplant recipient, not previously described elsewhere.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Kidney Transplantation / Coronavirus Infections / Glomerulonephritis Type of study: Case report / Observational study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Nephron Year: 2020 Document Type: Article Affiliation country: 000509938

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Kidney Transplantation / Coronavirus Infections / Glomerulonephritis Type of study: Case report / Observational study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Nephron Year: 2020 Document Type: Article Affiliation country: 000509938