Complement Inhibition with the C5 Blocker LFG316 in Severe COVID-19.

Zelek, Wioleta M; Cole, Jade; Ponsford, Mark J; Harrison, Richard A; Schroeder, Ben E; Webb, Nicholas; Jolles, Stephen; Fegan, Christopher; Morgan, Matt; Wise, Matt P; Morgan, B Paul

Zelek, Wioleta M; Cole, Jade; Ponsford, Mark J; Harrison, Richard A; Schroeder, Ben E; Webb, Nicholas; Jolles, Stephen; Fegan, Christopher; Morgan, Matt; Wise, Matt P; Morgan, B Paul.

Zelek WM; Cardiff University, Cardiff, United Kingdom.
Cole J; University Hospital of Wales, Cardiff, United Kingdom and.
Ponsford MJ; Cardiff University, Cardiff, United Kingdom.
Harrison RA; University Hospital of Wales, Cardiff, United Kingdom and.
Schroeder BE; Cardiff University, Cardiff, United Kingdom.
Webb N; University Hospital of Wales, Cardiff, United Kingdom and.
Jolles S; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Fegan C; University Hospital of Wales, Cardiff, United Kingdom and.
Morgan M; Cardiff University, Cardiff, United Kingdom.
Wise MP; Cardiff University, Cardiff, United Kingdom.
Morgan BP; University Hospital of Wales, Cardiff, United Kingdom and.

Am J Respir Crit Care Med ; 202(9): 1304-1308, 2020 11 01.

Article in English | MEDLINE | ID: covidwho-748841

Subject(s)

Betacoronavirus; Complement Inactivator Proteins/administration & dosage; Coronavirus Infections/drug therapy; Pneumonia, Viral/drug therapy; Adult; Aged; COVID-19; Coronavirus Infections/epidemiology; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Pandemics; Pneumonia, Viral/epidemiology; SARS-CoV-2; Treatment Outcome

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Complement Inactivator Proteins / Coronavirus Infections / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Am J Respir Crit Care Med Journal subject: Critical Care Year: 2020 Document Type: Article Affiliation country: Rccm.202007-2778LE

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