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[Investigation of pathogenic agents causing acute respiratory tract infections in pediatric patients in a children's hospital assigned for case screening in Beijing during the outbreak of COVID-19].
Zhao, L Q; Deng, L; Cao, L; Chen, D M; Sun, Y; Zhu, R N; Wang, F; Guo, Q; Zhou, Y T; Jia, L P; Huang, H; Kang, X H; Jin, F H; Yuan, Y; Zhang, N; De, R; Qian, Y.
  • Zhao LQ; Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China.
  • Deng L; Department of Infectious Diseases, Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.
  • Cao L; Department of Respiratory Diseases, Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.
  • Chen DM; Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China.
  • Sun Y; Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China.
  • Zhu RN; Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China.
  • Wang F; Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China.
  • Guo Q; Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China.
  • Zhou YT; Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China.
  • Jia LP; Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China.
  • Huang H; Department of Infectious Diseases, Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.
  • Kang XH; Department of Respiratory Diseases, Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.
  • Jin FH; Department of Infectious Diseases, Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.
  • Yuan Y; Department of Respiratory Diseases, Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.
  • Zhang N; Department of Infectious Diseases, Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.
  • De R; Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China.
  • Qian Y; Laboratory of Virology, Beijing Key Laboratory of Etiology of Viral Diseases in Children, Capital Institute of Pediatrics, Beijing 100020, China.
Zhonghua Er Ke Za Zhi ; 58(8): 635-639, 2020 Aug 02.
Article in Chinese | MEDLINE | ID: covidwho-749115
ABSTRACT

Objective:

To investigate the spectrum of pathogenic agents in pediatric patients with acute respiratory infections (ARI) during the outbreak of coronavirus infectious diseases 2019 (COVID-19).

Methods:

Three groups of children were enrolled into the prospective study during January 20 to February 20, 2020 from Capital Institute of Pediatrics, including children in the exposed group with ARI and epidemiological history associated with COVID-19 from whom both pharyngeal and nasopharyngeal swabs were collected, children in the ARI group without COVID-19 associated epidemiological history and children in the screening group for hospital admission, with neither COVID-19 associated epidemiological history nor ARI. Only nasopharyngeal swabs were collected in the ARI group and screening group. Each group is expected to include at least 30 cases. All specimens were tested for 2019-nCoV nucleic acid by two diagnostic kits from different manufacturers. All nasopharyngeal swabs were tested for multiple respiratory pathogens, whilst the results from the ARI group were compared with that in the correspondence periods of 2019 and 2018 used by t or χ(2) test.

Results:

A total of 244 children were enrolled into three groups, including 139 males and 105 females, the age was (5±4) years. The test of 2019-nCoV nucleic acid were negative in all children, and high positive rates of pathogens were detected in exposed (69.4%, 25/36) and ARI (55.3%, 73/132) groups, with the highest positive rate for mycoplasma pneumoniae (MP) (19.4%, 7/36 and 17.4%, 23/132, respectively), followed by human metapneumovirus (hMPV) (16.7%, 6/36 and 9.8%, 13/132, respectively). The positive rate (11.8%, 9/76) of pathogens in the screening group was low. In the same period of 2019, the positive rate of pathogens was 83.7% (77/92), with the highest rates for respiratory syncytial virus (RSV) A (29.3%, 27/92), followed by influenza virus (Flu) A (H1N1) (19.6%, 18/92) and adenovirus (ADV) (14.1%, 13/92), which showed significant difference with the positive rates of the three viruses in 2020 (RSV A χ(2)=27.346, P<0.01; FluA (H1N1) χ(2)=28.083, P<0.01; ADV χ(2)=7.848, P=0.005) . In 2018, the positive rate of pathogens was 61.0% (50/82), with the highest rate for human bocavirus (HBoV) (13.4%, 11/82) and followed by ADV (11.0%, 9/82), and significant difference was shown in the positive rate of HBoV with that in 2020 (χ(2)=6.776, P=0.009).

Conclusions:

The infection rate of 2019-nCoV is low among children in Beijing with no family clustering or no close contact, even with epidemiological history. The spectrum of pathogens of ARI in children during the research period is quite different from that in the previous years when the viral infections were dominant. MP is the highest positively detected one among the main pathogens during the outbreak of COVID-19 in Beijing where there is no main outbreak area.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Disease Outbreaks / Paramyxoviridae Infections / Metapneumovirus / Mycoplasma pneumoniae Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: Chinese Journal: Zhonghua Er Ke Za Zhi Year: 2020 Document Type: Article Affiliation country: Cma.j.cn112140-20200426-00437

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Disease Outbreaks / Paramyxoviridae Infections / Metapneumovirus / Mycoplasma pneumoniae Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: Chinese Journal: Zhonghua Er Ke Za Zhi Year: 2020 Document Type: Article Affiliation country: Cma.j.cn112140-20200426-00437