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[Clinical characteristics and outcomes of adult critically ill patients with COVID-19 in Honghu, Hubei Province].
Lu, Jiayin; Zhang, Yuan; Cheng, Gong; He, Jin; Wu, Feng; Hu, Hongbin; Sha, Tong; Zeng, Zhenhua; Chen, Zhongqing.
  • Lu J; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou510515, China.
  • Zhang Y; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou510515, China.
  • Cheng G; Department of Critical Care Medicine, Honghu People's Hospital of Jingzhou City, Jingzhou 433200, China.
  • He J; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou510515, China.
  • Wu F; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou510515, China.
  • Hu H; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou510515, China.
  • Sha T; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou510515, China.
  • Zeng Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou510515, China.
  • Chen Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou510515, China.
Nan Fang Yi Ke Da Xue Xue Bao ; 40(6): 778-785, 2020 Jun 30.
Article in Chinese | MEDLINE | ID: covidwho-749262
ABSTRACT

OBJECTIVE:

To explore the clinical characteristics and outcomes of adult critically ill patients with COVID-19 and identify the risk factors correlated with in-hospital deaths.

METHODS:

This study was conducted among 20 confirmed adult cases of COVID-19 in the Intensive Care Unit (ICU) of Honghu People's Hospital in Jingzhou City, Hubei Province. According to the final outcome, the patients were divided into survivor group and death group with 10 patients each. The demographic data, clinical manifestations and signs, laboratory findings, treatment measures and clinical outcomes were obtained from electronic medical records to compare the clinical characteristics and outcomes between the two groups. Univariate logistic analysis was used to analyze the risk factors associated with in-hospital death.

RESULTS:

The mean age of patients with confirmed COVID-19 was 70 ± 12 years, and 40% of them were male. The patients were admitted to ICU 11 ± 9 days after symptom onset. The most common symptoms on admission were cough (19 cases), fatigue or myalgia (18 cases), fever (17 cases) and dyspnea (16 cases). Eleven (55%) of the patients had underlying diseases, among which hypertension was the most common (11 cases), followed by cardiovascular disease (4 cases) and diabetes (3 cases). Six (30%) of the patients received invasive mechanical ventilation and continued renal replacement therapy but eventually died. Acute cardiac injury was the most common complication (19 cases). Half of the patients died between the 2nd and 19th day after ICU admission. Compared with dead patients, the surviving patients had a lower average body weight (61.70±2.36 vs 68.60±7.15 kg, P=0.01) and a higher Glasgow Coma Index (14.69 ± 0.70 vs 12.70 ± 2.45, P=0.03), and were less likely to develop shock (2 vs 10, P=0.001) or acute respiratory distress syndrome (2 vs 10, P=0.001).

CONCLUSIONS:

Critically ill patients with COVID-19 are generally older. A higher body weight and a lower lymphocyte count are potentially associated with a greater likeliness of fatality in ICU patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Critical Illness / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: Chinese Journal: Nan Fang Yi Ke Da Xue Xue Bao Year: 2020 Document Type: Article Affiliation country: J.issn.1673-4254.2020.06.02

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Critical Illness / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: Chinese Journal: Nan Fang Yi Ke Da Xue Xue Bao Year: 2020 Document Type: Article Affiliation country: J.issn.1673-4254.2020.06.02