Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review).
Int J Mol Med
; 46(3): 903-912, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-750592
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARSCoV2) is a novel ß coronavirus that is the etiological agent of the pandemic coronavirus disease 2019 (COVID19) that at the time of writing (June 16, 2020) has infected almost 6 million people with some 450,000 deaths. These numbers are still rising daily. Most (some 80%) cases of COVID19 infection are asymptomatic, a substantial number of cases (15%) require hospitalization and an additional fraction of patients (5%) need recovery in intensive care units. Mortality for COVID19 infection appears to occur globally between 0.1 and 0.5% of infected patients although the frequency of lethality is significantly augmented in the elderly and in patients with other comorbidities. The development of acute respiratory distress syndrome and episodes of thromboembolism that may lead to disseminated intravascular coagulation (DIC) represent the primary causes of lethality during COVID19 infection. Increasing evidence suggests that thrombotic diathesis is due to multiple derangements of the coagulation system including marked elevation of Ddimer that correlate negatively with survival. We propose here that the thromboembolic events and eventually the development of DIC provoked by SARSCoV2 infection may represent a secondary antiphospholipid antibody syndrome (APS). We will apply both Baconian inductivism and Cartesian deductivism to prove that secondary APS is likely responsible for coagulopathy during the course of COVID19 infection. Diagnostic and therapeutic implications of this are also discussed.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Thromboembolism
/
Thrombosis
/
Antiphospholipid Syndrome
/
Coronavirus Infections
/
Disseminated Intravascular Coagulation
Type of study:
Etiology study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Int J Mol Med
Journal subject:
Molecular Biology
/
Genetics, Medical
Year:
2020
Document Type:
Article
Affiliation country:
Ijmm.2020.4659
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