Your browser doesn't support javascript.
Anosmia and Ageusia as Predictive Signs of COVID-19 in Healthcare Workers in Italy: A Prospective Case-Control Study.
La Torre, Giuseppe; Massetti, Anna Paola; Antonelli, Guido; Fimiani, Caterina; Fantini, Mauro; Marte, Mattia; Faticoni, Augusto; Previte, Carlo Maria; Turriziani, Ombretta; Pugliese, Francesco; Villari, Paolo; Romano, Ferdinando; Mastroianni, Claudio Maria.
  • La Torre G; Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Massetti AP; Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Antonelli G; Department of Infectious Diseases, Teaching Hospital "Policlinico Umberto I", Sapienza University, 00185 Rome, Italy.
  • Fimiani C; Department of Molecular Medicine, Teaching Hospital "Policlinico Umberto I", Sapienza University, 00185 Rome, Italy.
  • Fantini M; Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Marte M; Department of Infectious Diseases, Teaching Hospital "Policlinico Umberto I", Sapienza University, 00185 Rome, Italy.
  • Faticoni A; Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Previte CM; Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Turriziani O; Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Pugliese F; Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Villari P; Department of Molecular Medicine, Teaching Hospital "Policlinico Umberto I", Sapienza University, 00185 Rome, Italy.
  • Romano F; Division of Anesthesiology and Intensive Care, Teaching Hospital "Policlinico Umberto I", Sapienza University of Rome, 00185 Rome, Italy.
  • Mastroianni CM; Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Covid-Sapienza Collaborative Group; Department of Public health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
J Clin Med ; 9(9)2020 Sep 04.
Article in English | MEDLINE | ID: covidwho-750664
ABSTRACT

BACKGROUND:

The aim of this study was to investigate the diagnostic accuracy of symptoms and signs in healthcare workers (HCW) with Sars-CoV-2.

METHODS:

This was a case-control study. Cases consisted of symptomatic healthcare workers who had a positive SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) test, while controls were symptomatic healthcare workers with a negative RT-PCR test. For each symptom, ROCs were plotted. Diagnostic accuracy was calculated using the sensitivity, specificity, and positive and negative predictive values. A logistic regression analysis was carried out for calculating the OR (95% CI) for each symptom associated to the SARS-CoV-2 positivity.

RESULTS:

We recruited 30 cases and 75 controls. Fever had the best sensitivity while dyspnea, anosmia, and ageusia had the highest specificity. The highest PPVs were found again for dyspnea (75%), anosmia (73.7%), and ageusia (66.7%). Lastly, the highest NPVs were related to anosmia (81.4%) and ageusia (79.3%). Anosmia (OR = 14.75; 95% CI 4.27-50.87), ageusia (OR = 9.18; 95% CI 2.80-30.15), and headache (OR = 3.92; 95% CI 1.45-10.56) are significantly associated to SARS-CoV-2 positivity.

CONCLUSIONS:

Anosmia and ageusia should be considered in addition to the well-established fever, cough, and dyspnea. In a resource-limited setting, this method could save time and money.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Year: 2020 Document Type: Article Affiliation country: Jcm9092870

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Year: 2020 Document Type: Article Affiliation country: Jcm9092870