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Can data from paediatric cohorts solve the COVID-19 puzzle?
Do, Lien Anh Ha; Anderson, Jeremy; Mulholland, Edward Kim; Licciardi, Paul V.
  • Do LAH; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia.
  • Anderson J; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
  • Mulholland EK; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia.
  • Licciardi PV; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia.
PLoS Pathog ; 16(9): e1008798, 2020 09.
Article in English | MEDLINE | ID: covidwho-751007
ABSTRACT
COVID-19, caused by SARS-CoV-2, is significantly more severe in adults than in children. The biological reasons for this difference remain to be elucidated. We have compared the most recent virological and immunological data related to COVID-19 between adults and children and contrasted this with earlier data from severe acute respiratory syndrome (SARS) caused by the related SARS-CoV-1 in 2003. Based on these available data, a number of hypotheses are proposed to explain the difference in COVID-19 clinical outcomes between adults and children. NF-kB may be a key factor that could explain the severe clinical manifestations of COVID-19 in adults as well as rare complications associated with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in paediatric COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / NF-kappa B / Age Factors / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Child / Humans Language: English Journal: PLoS Pathog Year: 2020 Document Type: Article Affiliation country: Journal.ppat.1008798

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / NF-kappa B / Age Factors / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Child / Humans Language: English Journal: PLoS Pathog Year: 2020 Document Type: Article Affiliation country: Journal.ppat.1008798