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Hydroxychloroquine and COVID-19.
Sinha, Neeraj; Balayla, Galit.
  • Sinha N; Pulmonary Transplant, University of Miami Miller School of Medicine, Miami, Florida, USA nsinhamd@yahoo.com.
  • Balayla G; General Medicine, Central University of Venezuela, Caracas, Venezuela.
Postgrad Med J ; 96(1139): 550-555, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-751468
ABSTRACT
Hydroxychloroquine and chloroquine are medications that have been used for a long time. Their most common use is for the treatment and prophylaxis of malaria. However, these antimalarial drugs are known to also have anti-inflammatory and antiviral effects and are used for several chronic diseases such as systemic lupus erythematosus with low adverse effects. The antiviral action of hydroxychloroquine and chloroquine has been a point of interest to different researchers due to its mechanism of action. Several in vitro studies have proven their effectiveness on severe acute respiratory syndrome virus and currently both in vitro and in vivo studies have been conducted on 2019 novel coronavirus (covid-19). The purpose of this article is to review the history and mechanism of actions of these drugs and the potential use they can have on the current covid-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Hydroxychloroquine / Antimalarials Type of study: Prognostic study Limits: Humans Language: English Journal: Postgrad Med J Year: 2020 Document Type: Article Affiliation country: Postgradmedj-2020-137785

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Hydroxychloroquine / Antimalarials Type of study: Prognostic study Limits: Humans Language: English Journal: Postgrad Med J Year: 2020 Document Type: Article Affiliation country: Postgradmedj-2020-137785