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Paradoxical effect of SARS-CoV-2 infection in patients with immune thrombocytopenia.
de la Cruz-Benito, Beatriz; Rivas-Pollmar, María I; Álvarez Román, María T; Trelles-Martínez, Roberto; Martín-Salces, Monica; Lázaro-Del Campo, Paula; Ramírez-López, Andrés; García-Barcenilla, Sara; Cebanu, Tamara; Acuña-Butta, Paula; Monzón-Manzano, Elena; González-Zorrilla, Elena; Jiménez-Yuste, Victor; Butta, Nora V.
  • de la Cruz-Benito B; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Rivas-Pollmar MI; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Álvarez Román MT; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Trelles-Martínez R; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Martín-Salces M; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Lázaro-Del Campo P; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Ramírez-López A; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • García-Barcenilla S; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Cebanu T; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Acuña-Butta P; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Monzón-Manzano E; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • González-Zorrilla E; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Jiménez-Yuste V; Unit of Thrombosis and Hemostasis, Hematology Department, La Paz University Hospital - IdiPAZ, Madrid, Spain.
  • Butta NV; Autonoma University of Madrid, Madrid, Spain.
Br J Haematol ; 192(6): 973-977, 2021 03.
Article in English | MEDLINE | ID: covidwho-751791
ABSTRACT
Thrombocytopenia has been identified as a common complication of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the general population. In an attempt to determine the impact of coronavirus disease 2019 (COVID-19) in patients with immune thrombocytopenia (ITP), a retrospective single-centre study was performed. Thrombocytosis was observed in patients with chronic ITP after SARS-CoV-2 infection, frequently needing treatment adjustment or even discontinuation of therapy. Relapses and newly diagnosed cases showed a fast response after initial treatment compared to ITP. Reduced immune activity due to lymphopenia during COVID-19 could explain this paradoxical effect, although further studies are needed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / COVID-19 Type of study: Experimental Studies / Observational study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Br J Haematol Year: 2021 Document Type: Article Affiliation country: Bjh.17077

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / COVID-19 Type of study: Experimental Studies / Observational study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Br J Haematol Year: 2021 Document Type: Article Affiliation country: Bjh.17077