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Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus.
Banerjee, Arinjay; Doxey, Andrew C; Tremblay, Benjamin J-M; Mansfield, Michael J; Subudhi, Sonu; Hirota, Jeremy A; Miller, Matthew S; McArthur, Andrew G; Mubareka, Samira; Mossman, Karen.
  • Banerjee A; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Doxey AC; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Tremblay BJ; Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
  • Mansfield MJ; Division of Respirology, Department of Medicine, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Subudhi S; Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
  • Hirota JA; Genomics and Regulatory Systems Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa 904-0495, Japan.
  • Miller MS; Gastrointestinal Unit and Liver Center, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, MA 02114, USA.
  • McArthur AG; Division of Respirology, Department of Medicine, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Mubareka S; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Mossman K; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
J Gen Virol ; 101(12): 1251-1260, 2020 12.
Article in English | MEDLINE | ID: covidwho-1066517
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged to cause widespread infections in humans. SARS-CoV-2 infections have been reported in the Kingdom of Saudi Arabia, where Middle East respiratory syndrome coronavirus (MERS-CoV) causes seasonal outbreaks with a case fatality rate of ~37 %. Here we show that there exists a theoretical possibility of future recombination events between SARS-CoV-2 and MERS-CoV RNA. Through computational analyses, we have identified homologous genomic regions within the ORF1ab and S genes that could facilitate recombination, and have analysed co-expression patterns of the cellular receptors for SARS-CoV-2 and MERS-CoV, ACE2 and DPP4, respectively, to identify human anatomical sites that could facilitate co-infection. Furthermore, we have investigated the likely susceptibility of various animal species to MERS-CoV and SARS-CoV-2 infection by comparing known virus spike protein-receptor interacting residues. In conclusion, we suggest that a recombination between SARS-CoV-2 and MERS-CoV RNA is possible and urge public health laboratories in high-risk areas to develop diagnostic capability for the detection of recombined coronaviruses in patient samples.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Reassortant Viruses / Middle East Respiratory Syndrome Coronavirus / SARS-CoV-2 Type of study: Diagnostic study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Journal: J Gen Virol Year: 2020 Document Type: Article Affiliation country: Jgv.0.001491

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Reassortant Viruses / Middle East Respiratory Syndrome Coronavirus / SARS-CoV-2 Type of study: Diagnostic study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Journal: J Gen Virol Year: 2020 Document Type: Article Affiliation country: Jgv.0.001491