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The efficacy of colchicine in the management of coronavirus disease 2019: A protocol for systematic review and meta-analysis.
Elshafei, Mohamed Nabil; Khalil, Ahmed; El-Bardissy, Ahmed; Danjuma, Mohammed; Ahmed, Mohamed Badie; Mohamed, Mouhand F H.
  • Elshafei MN; Clinical Pharmacy Department. Hamad General Hospital.
  • Khalil A; Clinical Pharmacy Department. Hamad General Hospital.
  • El-Bardissy A; Clinical Pharmacy Department. Hamad General Hospital.
  • Danjuma M; Internal Medicine Department, Hamad Medical Corporation.
  • Ahmed MB; College of Medicine, QU Health, Qatar University, Doha, Qatar.
  • Mohamed MFH; College of Medicine, QU Health, Qatar University, Doha, Qatar.
Medicine (Baltimore) ; 99(36): e21911, 2020 Sep 04.
Article in English | MEDLINE | ID: covidwho-752029
Semantic information from SemMedBD (by NLM)
1. colchicine TREATS COVID-19
Subject
colchicine
Predicate
TREATS
Object
COVID-19
2. Virus Diseases CAUSES upper respiratory symptom
Subject
Virus Diseases
Predicate
CAUSES
Object
upper respiratory symptom
3. chemokine CAUSES Inflammatory Response
Subject
chemokine
Predicate
CAUSES
Object
Inflammatory Response
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. colchicine PREVENTS Coronavirus Infections
Subject
colchicine
Predicate
PREVENTS
Object
Coronavirus Infections
6. colchicine TREATS COVID-19
Subject
colchicine
Predicate
TREATS
Object
COVID-19
7. Virus Diseases CAUSES upper respiratory symptom
Subject
Virus Diseases
Predicate
CAUSES
Object
upper respiratory symptom
8. chemokine CAUSES Inflammatory Response
Subject
chemokine
Predicate
CAUSES
Object
Inflammatory Response
9. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
10. colchicine PREVENTS Coronavirus Infections
Subject
colchicine
Predicate
PREVENTS
Object
Coronavirus Infections
ABSTRACT

BACKGROUND:

Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) infection is a recently emerged viral infection causing predominantly mild upper respiratory symptoms. However, in some instances, it might result in acute respiratory distress syndrome (ARDS) that poses a significant mortality risk. ARDS is postulated to be mediated by a surge of pro-inflammatory cytokines and chemokines, leading to a dysregulated hyper inflammatory response. Colchicine being an anti-inflammatory agent, might mitigate this dysregulated response. Thus, in the absence of therapeutic options available to manage coronavirus disease 2019 (COVID-19), it is imperative to ascertain the effect of colchicine on improving outcomes in COVID-19 patients.

METHOD:

We will perform a systematic review including a search of the following databases PubMed, EMBASE, MEDLINE, Clinicaltrials.gov, Cochrane library, and google scholar since inception. We will include randomized controlled trials exploring the effect of colchicine on the efficacy and safety outcomes of COVID-19 patients. Subsequently, we will perform a meta-analysis utilizing the random-effects to ascertain the effect of colchicine on reducing COVID-19 related mortality (primary endpoint) and other efficacy and safety outcomes.

RESULTS:

Our review results are anticipated in early 2021 (based on the completion of several ongoing randomized controlled trial). Our review results will be published in a peer-reviewed journal.

CONCLUSION:

This systematic review and meta-analysis, is exploring the effect of colchicine on the efficacy and safety outcomes of COVID-19 patients. If colchicine proved to be effective, it would be a significant milestone in the management of COVID-19, a disease with limited available therapeutic options. PROSPERO REGISTRATION NUMBER CRD42020191086.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Colchicine / Coronavirus Infections / Anti-Inflammatory Agents Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Medicine (Baltimore) Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Colchicine / Coronavirus Infections / Anti-Inflammatory Agents Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Medicine (Baltimore) Year: 2020 Document Type: Article